Abstract
The use of human embryonic stem cells to replace damaged cells and tissues promises future hope for the treatment of many diseases. However, many countries now face complex ethical and legal questions as a result of the research needed to develop these cell-replacement therapies. The challenge that must be met is how to permit research on human embryonic tissue to occur while maintaining respect for human life generally.
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References
Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145–1147 ( 1998).
Shamblott, M. J. et al. Derivation of pluripotent stem cells from cultured human primoridial germ cell. Proc. Natl Acad. Sci. USA 95, 13726–13731 (1998).
Reubinoff, B. E., Pera, M. F., Fong, C. -Y., Trounson, A. & Bongso, A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nature Biotechnol. 18, 399–404 ( 2000).
Andrews, L. State regulation of embryo research, (National Institutes of Health, Papers Commissioned for the Human Embryo Research Panel, Vol. II 1994).
Public Law No. 105–277, 112 Stat. 2681 ( 1998).
National Institutes of Health. National Institute of Health Guidelines for Research using Human Pluripotent Stem Cells. Federal Register 65 FR 51976–51981 (2000).
Department of Health. Stem Cell Research: Medical Progress with Responsibility A report from the chief medical officer's expert group reviewing the potential of developments in stem cell research and cell nuclear replacement to benefit human health (London, June, 2000).
France: Law No. 94-654 No. 175. 11060–11068 (Journal officiel de la République française, Lois et Decret, 30 July 1994).
Germany: Law of 13 December 1990 for the protection of embryos (the Embryo Protection Law), (Bundesgestetzblatt, Part I, 2746–2748, 19 December 1990).
The Infertility Treatment Act 1995 (Act No. 63/1995).
Szoke, H. in Controversies in Health Law (eds Freckelton, I. & Peterson, K.) 242–243 (Federation, Melbourne, 1999 ).
Michigan Public Acts 108 (Michigan Comp. Laws #333. 16274) (1998).
Clarke, D. L. et al. Generalized potential of adult neural stem cells. Science 288, 1660–1663 ( 2000).
Dworkin, R. M. Life's Dominion: An Argument About Abortion, Euthanasia, and Individual Freedom (Knopf, New York, 1993).
Feinberg, J. Harm to Others: The Moral Limits of the Criminal Law (Oxford Univ. Press, New York, 1986).
Tooley, M. Abortion and infanticide. Phil. Pub. Affairs 2, 1–31 (1972).
Grobstein, C. The early development of human embryos. J. Med. Phil. 10, 213–220 (1985).
Robertson, J. A. Children of Choice: Freedom and the New Reproductive Technologies (Princton Univ. Press, Princeton, 1994).
American Fertility Society. Ethical considerations in the use of new reproductive technologies. Fertil. Steril. 46, S5–S7 (1986).
Robertson, J. A. Symbolic issues in embryo research. Hastings Center Report 25, 37–38 (1995).
Ad Hoc group of consultants to the advisory committee to the Director, NIH. Report of the Human Embryo Research Panel . (National Institutes of Health, Bethesda, Maryland, 1994).
National Bioethics Advisory Commission. The Ethical Use of Human Stem Cells in Research (National Bioethics Advisory Commission, Rockville, Maryland, 1999).
National Institutes of Health Revitalization Act of 1993, Pub. L. No. 10–43, Sect. 111, 107 Stat. 129 (codified at 42 U. S. C. Sec. 498A).
Solter, D. Mammalian cloning: advances and limitations. Nature Rev. Genet. 1, 199–207 ( 2000).
Robertson, J. A. Embryo research. Western Ontario Law Rev. 24, 15–37 (1986).
Annas, G. A., Caplan, A. & Elias, S. The politics of human-embryo research — avoiding ethical gridlock. N. Engl. J. Med. 334, 1329–1332 (1996).
Lanza, R. P. et al. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science 288, 666–669 (2000).
Cohen, C. B. (ed.) New Ways of Making Babies: The Case of Egg Donation (Indiana University, Bloomington, Indiana, 1996).
Wade, N. Ethics panel is guarded about hybrid of cow cells. New York Times A7 21 December 1998 ).
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FURTHER INFORMATION
Parliament advisory group's recommendations on therapeutic cloning
The United States Congress' ban on federal funding of human embryo research
Council of Europe's Convention on Human Rights and Biomedicine
UNESCO's Universal Declaration on the Human Genome and Human Rights
Glossary
- TROPHOBLAST CELLS
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Cells that contribute to the placenta but not to the embryo itself and that are required for an embryo to implant into the uterine wall.
- INNER CELL MASS
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Cells that give rise to the embryo proper and that arise from the inner cells of an early preimplantation embryo.
- BLASTOCYST
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A preimplantation embryo that contains a fluid-filled cavity called a blastocoel.
- CLEAVAGE
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The mitotic divisions of the early embryo that occur in the absence of growth to divide the embryo into many smaller nucleated cells.
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Robertson, J. Human embryonic stem cell research: ethical and legal issues. Nat Rev Genet 2, 74–78 (2001). https://doi.org/10.1038/35047594
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DOI: https://doi.org/10.1038/35047594
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