Current Issue


Research Highlights

Genome organization: In the beginning there was order | PDF (299 KB)

p327 | doi:10.1038/nrg.2017.37

Technique: A mosaic of enhancer function in single cells | PDF (392 KB)

p328 | doi:10.1038/nrg.2017.34

Mutations: Dawn of the Human Knockout Project | PDF (155 KB)

p328 | doi:10.1038/nrg.2017.35

Evolutionary genetics: Fantastic beasts — cephalopod RNA recoding | PDF (184 KB)

p329 | doi:10.1038/nrg.2017.31

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Reviews

Article series: Disease mechanisms

Genetics of coronary artery disease: discovery, biology and clinical translation

Amit V. Khera & Sekar Kathiresan

p331 | doi:10.1038/nrg.2016.160

The past decade has seen tremendous progress in understanding the genetic architecture of coronary artery disease (CAD). Khera and Kathiresan review research efforts that have improved our understanding of the genetic drivers of CAD, and discuss the promises and challenges of integrating genetic information into routine clinical practice.

Article series: Single-cell omics

Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices

Sanjay M. Prakadan, Alex K. Shalek & David A. Weitz

p345 | doi:10.1038/nrg.2017.15

As the genetic and phenotypic heterogeneities among cells become more appreciated, there is increasing demand for technologies that facilitate high-throughput and high-efficiency single-cell 'omic' analyses in miniaturized and automated formats. This Review discusses the diverse microfluidic methodologies — with a primary focus on valve-, droplet- and nanowell-based platforms — for characterization of the genomes, epigenomes, transcriptomes and proteomes of single cells, and addresses technical considerations and future opportunities.

Article series: Translational genetics

Autism genetics: opportunities and challenges for clinical translation

Jacob A. S. Vorstman, Jeremy R. Parr, Daniel Moreno-De-Luca, Richard J. L. Anney, John I. Nurnberger Jr & Joachim F. Hallmayer

p362 | doi:10.1038/nrg.2017.4

Various large studies have provided unprecedented insights into the genetics of autism spectrum disorders (ASDs). This Review discusses the challenges and opportunities of translating genetic and biological insights into clinical progress for ASDs, in areas including genetic testing, ASD classification, genetic counselling, comorbidities and therapeutics.

The X chromosome in space

Teddy Jégu, Eric Aeby & Jeannie T. Lee

p377 | doi:10.1038/nrg.2017.17

Three-dimensional genome organization can shape gene expression by facilitating interactions between regulatory elements. The authors review the process of X-chromosome inactivation with a focus on chromatin organization and subnuclear localization of the active and inactive X chromosomes, as well as the potential roles of long non-coding RNAs.