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High-throughput technologies are starting to be applied to assess the complex molecular changes that occur with increasing age in humans. This Progress article introduces the emerging findings for transcriptomics, epigenomics, metabolomics and other 'omics' approaches.
Increasing evidence suggests that parent-of-origin effects, particularly genomic imprinting, contribute to complex traits. This Review discusses how such effects can be identified in order to expand our understanding of their roles in phenotypes such as human diseases and traits important for agriculture.
Technologies that are based on next-generation sequencing are increasingly being used to study individual cells. The authors discuss the application of this approach to single-cell genomics and transcriptomics, and explore the implications for both basic research and medicine.
This Review considers mechanisms by which information is transmitted over short and long distances during plant development and how different modes of signalling integrate with gene regulatory networks to allow plants to respond to their environment.
Genes that have originated in recent evolution are present in only a subset of organisms and are often assumed to be dispensable or redundant. This Review discusses our latest understanding of how new genes in diverse species have actually evolved to have important functions in diverse developmental and physiological processes in various organisms.
Research into the genetics of immune and inflammatory disease has experienced major recent advances owing to the availability of a custom single-nucleotide polymorphism (SNP) genotyping array — the Immunochip — developed specifically to investigate these disorders. In this Analysis, the authors assess findings from studies that have used this platform, and explore the shared and phenotype-specific genetic associations among several immune-mediated diseases.
