Abstract

Research in genetics and genomics has led to an expanding list of molecular genetic tests, which are increasingly entering health care systems. However, the evidence surrounding the benefits and harms of these tests is frequently weak. Here we present the main challenges to the successful translation of new research findings about genotype–phenotype associations into clinical practice. We discuss the means to achieve an accelerated translation research agenda that is conducted in a reasonable, fair and efficient manner.

Author affiliations

1. Wolf H. Rogowski is at the Helmholtz Center Munich, German Research Center for Environmental Health (GmbH), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
2. Scott D. Grosse is at the National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS E88, Atlanta, Georgia 30333, USA.
3. Muin J. Khoury is at the Office of Public Health Genomics, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS E61, Atlanta, Georgia 30333, USA.

Correspondence to: Wolf H. Rogowski¹ Email: rogowski@helmholtz-muenchen.de

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