Table of contents


From the editors

p659 | doi:10.1038/nrg2679

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Research Highlights

Synthetic biology: Avoiding the chop | PDF (151 KB)

p660 | doi:10.1038/nrg2671

Chromosome biology: Getting your Ys crossed | PDF (133 KB)

p661 | doi:10.1038/nrg2672

Technology: A step closer to personal genomics? | PDF (128 KB)

p661 | doi:10.1038/nrg2675

Human disease: iPSCs take the next step | PDF (133 KB)

p662 | doi:10.1038/nrg2667

Gene regulation: UTR cutbacks give free rein to oncogenes | PDF (134 KB)

p662 | doi:10.1038/nrg2668

In brief

Human disease | Evolution | Gene regulatory networks | PDF (119 KB)

p662 | doi:10.1038/nrg2677

Human epigenomics: Putting epigenetic variation on the map | PDF (122 KB)

p663 | doi:10.1038/nrg2676

Chromatin: A peak for exons | PDF (190 KB)

p664 | doi:10.1038/nrg2669

Epigenetics: Jump-starting transposons | PDF (153 KB)

p664 | doi:10.1038/nrg2674

In brief

Chromatin | Population genetics | Circadian rhythms | PDF (121 KB)

p665 | doi:10.1038/nrg2678

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Reviews

ChIP–seq: advantages and challenges of a maturing technology

Peter J. Park

p669 | doi:10.1038/nrg2641

Coupling next-generation sequencing to chromatin immunoprecipitation has transformed the resolution and genomic coverage of DNA-binding protein and nucleosome mapping studies. However, successful ChIP–seq requires careful consideration of the experimental and analytical approaches; this Review evaluates the current strategies and challenges.

Article series: Modelling

Bayesian statistical methods for genetic association studies

Matthew Stephens & David J. Balding

p681 | doi:10.1038/nrg2615

Bayesian analyses are increasingly being used in genetics, particularly in the context of genome-wide association studies. This article provides a guide to using Bayesian analyses for assessing single-SNP associations and highlights the advantages of these methods compared with standard frequentist analyses.

The impact of retrotransposons on human genome evolution

Richard Cordaux & Mark A. Batzer

p691 | doi:10.1038/nrg2640

The ability of mobile genetic elements to move and multiply means that they have a unique influence on genome sequences. Developments in comparative genomics have shown how important non-long terminal repeat retrotransposons have been in shaping the human genome.

Causes and consequences of microRNA dysregulation in cancer

Carlo M. Croce

p704 | doi:10.1038/nrg2634

Alterations in microRNA function contribute to the pathogenesis of many cancers. Recent studies have shown that such changes can result not only from mutations but also from epigenetic silencing or the dysregulation of transcription factors that target specific microRNAs.

The evolutionary consequences of erroneous protein synthesis

D. Allan Drummond & Claus O. Wilke

p715 | doi:10.1038/nrg2662

Disparate fields have provided advances in our understanding of the impact of protein-synthesis errors on cellular fitness, disease and evolution. Although organisms show adaptations to minimize the deleterious effects of such errors, erroneous protein synthesis can also be exploited for the organism's benefit.

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Perspectives

Opinion

The evolutionary significance of ancient genome duplications

Yves Van de Peer, Steven Maere & Axel Meyer

p725 | doi:10.1038/nrg2600

The authors argue that ancient whole-genome duplications might be linked to major ecological upheavals and extinction. When established, polyploidy might lead to increased vigour, species diversity and phenotypic novelties, and could therefore contribute to the evolutionary success of a lineage.

See also: Correspondence by Abbasi | Correspondence by Van de Peer et al.

Correspondence

Correspondence: Non-invasive prenatal diagnosis: an ethical imperative

Vardit Ravitsky

p733 | doi:10.1038/nrg2631-c1

Correspondence: Reply: Non-invasive prenatal diagnosis: an ethical imperative

Dagmar Schmitz, Christian Netzer & Wolfram Henn

p733 | doi:10.1038/nrg2631-c2