Gene regulation: Modelling by building blocks | PDF (232 KB)

p3 | doi:10.1038/nrg2510

Genomics: Distinguishing drivers from passengers | PDF (193 KB)

p4 | doi:10.1038/nrg2512

Ageing: A SIRTain role in ageing | PDF (158 KB)

p4 | doi:10.1038/nrg2514

Imprinting: Transcriptomics delivers | PDF (120 KB)

p4 | doi:10.1038/nrg2515

Human disease: Genome-wide insights into lipid levels | PDF (154 KB)

p5 | doi:10.1038/nrg2513

Plant development: Growing with time | PDF (193 KB)

p6 | doi:10.1038/nrg2508

Evolution: Something new | PDF (173 KB)

p6 | doi:10.1038/nrg2511

Genotype–phenotype databases: challenges and solutions for the post-genomic era

Gudmundur A. Thorisson, Juha Muilu & Anthony J. Brookes

p9 | doi:10.1038/nrg2483

Rapid increases in the quantity and complexity of data generated by modern biological research present huge challenges for database resources. Revised database models and web-based technological advances could lead to powerful new tools for disseminating and interpreting genotype–phenotype information.

• Abstract
• Full Text
• PDF (464 KB)

RNA-based gene duplication: mechanistic and evolutionary insights

Henrik Kaessmann, Nicolas Vinckenbosch & Manyuan Long

p19 | doi:10.1038/nrg2487

Gene duplication can occur via insertion of reverse transcribed mRNAs into the genome. Although originally thought to be non-functional, recent studies have uncovered how these retrocopies can acquire novel functions, and how patterns of retroposition can give unexpected insights into genome evolution.

• Abstract
• Full Text
• PDF (982 KB)

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Michael Haberland, Rusty L. Montgomery & Eric N. Olson

p32 | doi:10.1038/nrg2485

The expression of many histone deacetylase (HDAC) isoforms in eukaryotic cells raises questions regarding their specificity and the programmes of gene expression that they control. HDAC knockout mice are a powerful tool for addressing these questions and have revealed that individual HDACs have specific functions in development and disease.

• Abstract
• Full Text
• PDF (684 KB)

Detecting shared pathogenesis from the shared genetics of immune-related diseases

Alexandra Zhernakova, Cleo C. van Diemen & Cisca Wijmenga

p43 | doi:10.1038/nrg2489

Recent genome-wide association studies have provided evidence that some genetic loci are associated with disease susceptibility for several different immune-related disorders. Analysis of shared genetics can highlight shared pathogenic pathways that could become the focus for therapeutic intervention.

• Abstract
• Full Text
• PDF (543 KB)
• Supplementary information