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In this Comment, the authors highlight caveats about using African ethnicities as population categories in genomics research and emphasize the need for an Africa-oriented humanities research agenda to inform genomics research.
Somatic mutations accumulate with age in the genome of healthy individuals. Franco and Eriksson posit that recent sequencing data indicate a functional role for this increased mutational load in ageing and age-associated diseases.
To mark the bicentenary of Gregor Mendel’s birth, the authors reflect on progress in the application of genetics and genomics to delivering a cure for sickle cell disease, a classic Mendelian disorder.
On the occasion of Gregor Mendel’s bicentenary, the authors reflect on the history of the terms dominant and recessive, and their current use in medical genetics.