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Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cancer. In this Perspectives article, Xilin Yang and colleagues discuss risk factors (subphenotypes) for cancer in Chinese patients with T2DM, which can lead to drug-subphenotype interactions. The authors also propose plausible biological links between T2DM and cancer and underlying the drug-subphenotype interactions.
Successful studies in the nonobese diabetic (NOD) mouse model often do not translate to positive outcomes in human studies. This Perspectives outlines the genetic and immunologic differences that might contribute to these differential outcomes and suggests how the NOD mouse model could be adapted to improve its utility.
