Reviews & Analysis

This PrimeView highlights the pathophysiology of Helicobacter pylori infection and summarizes its epidemiology, diagnosis and management. It accompanies the Primer on this topic by Malfertheiner and colleagues.

Helicobacter pylori infection causes chronic gastritis and can lead to severe gastroduodenal pathologies, including peptic ulcer and gastric cancer. This Primer summarizes the epidemiology, pathophysiology, diagnosis and management of this infection, and discusses patient quality of life and open research questions.

This PrimeView highlights the epidemiology of chikungunya fever and summarizes its pathophysiology, diagnosis and management. It accompanies the Primer on this topic by Bartholomeeusen and colleagues.

Chikungunya fever is an acute febrile illness caused by chikungunya virus, a mosquito-borne alphavirus. This Primer by Bartholomeeusen and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of chikungunya fever, and discusses patient quality of life and open research questions for this condition.

This PrimeView highlights the diagnosis of intracerebral haemorrhage and accompanies the Primer article on the same topic by Cordonnier and colleagues.

This Primer by Cordonnier and colleagues describes the epidemiology, aetiology, pathophysiology, diagnosis and treatment of intracerebral haemorrhage.

This PrimeView highlights the pathogenesis of monogenic diabetes, a group of predominantly early-onset disorders that are caused by single genetic alterations.

Monogenic diabetes encompasses forms of diabetes that result from a single pathogenic genetic alteration and usually have an early onset. This Primer gives an overview of the epidemiology, pathophysiology, diagnosis and treatment of these conditions, as well as patient quality of life and open research questions.

This PrimeView summarizes the pathophysiology of fetal alcohol spectrum disorders, a group of conditions that occur in children exposed prenatally to alcohol.

Fetal alcohol spectrum disorders (FASD) are characterized by neurodevelopmental impairment with or without facial dysmorphology, congenital anomalies and poor growth. This Primer discusses the epidemiology, pathophysiology, diagnosis and treatment of FASD.

This PrimeView highlights the diagnosis of pre-eclampsia and summarizes its epidemiology, pathophysiology and management. It accompanies the Primer on this topic by Dimitriadis and colleagues.

Pre-eclampsia is a life-threatening disease of pregnancy and a leading cause of maternal and neonatal morbidity and mortality. This Primer by Dimitriadis and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of pre-eclampsia, and discusses patient quality of life and open research questions for this condition.

This PrimeView highlights the pathophysiology of medication overuse headache, a secondary headache disorder caused by overuse of acute headache medications by individuals with underlying headache disorders.

Medication overuse headache is a secondary headache disorder that occurs in those with a primary headache disorder (commonly tension-type headache or migraine). This Primer reviews the epidemiology, pathophysiology, diagnosis and treatment of medication overuse headache, and discusses how this disorder affects the quality of life of patients.

This PrimeView highlights the mechanisms of ichthyosis and summarizes its epidemiology, diagnosis and management. It accompanies the Primer on this topic by Gutiérrez-Cerrajero and colleagues.

The ichthyoses are a group of dermatological disorders characterized by generalized scaly, erythematous skin, accompanied by epidermal barrier function disruptions. This Primer by Gutiérrez-Cerrajero and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of ichthyosis, and discusses patient quality of life and open research questions for this condition.

This PrimeView summarizes strategies for the prevention of alcohol use disorders (AUDs) and accompanies the Primer on Hazardous drinking and AUDs by MacKillop and colleagues.

Hazardous drinking and alcohol use disorder are associated with substantial harms to both the individual and others. This Primer discusses the epidemiology, mechanisms, diagnosis and management of these disorders, and also summarizes screening, prevention and the quality of life issues faced by individuals with these disorders.

This PrimeView highligths Burkitt lymphoma, an aggressive form of B cell lymphoma that can affect children and adults. Most patients with BL can be treated successfully with chemotherapy, but new therapeutic approaches are required for relapsed or refractory disease.

Burkitt lymphoma is an aggressive form of B cell lymphoma that can affect children and adults. Its research has been central in advancing haematopathology and cancer research. This Primer by Siebert and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of this disorder, patient quality of life and open research questions.