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Spina bifida is a congenital disorder caused by failed closure of the neural tube, which leads to sensory, motor and cognitive dysfunction. Copp et al. discuss the prevalence and pathogenesis of spina bifida, as well as preventive actions, diagnostic methods and treatment options.
Huntington disease is an autosomal dominant neurological disorder caused by mutation in HTT. As illustrated here, the disease typically manifests in adulthood and is characterized by progressive motor, cognitive and behavioural impairment.
Menopause is the age-related (primary) or iatrogenic (secondary) loss of female reproductive function. Menopausal women are at increased risk for many conditions including cardiovascular disease, osteoporosis and some cancers, by mechanisms that are not yet fully understood.
Nature Reviews Disease Primers will cover 'classic' diseases, consequences of ageing, behavioural conditions, developmental disorders and nutritional deficiencies — all of which have important consequences for human health.
Systemic sclerosis is an autoimmune disease characterized by vasculopathy-induced fibrosis of the skin and organs that can be life-threatening. This PrimeView summarizes the mechanisms underlying the condition, how patients are diagnosed and the quality of life of patients.
Melanoma is one of the most common cancers in the West, and the research arena is bustling; advances in immunotherapy and genomics are reflected in the increasing survival of patients. These advances are summarized in this PrimeView.
Melanoma is one of the most common cancers in the West, and the research arena is bustling; advances in immunotherapy and genomics are reflected in the increasing survival of patients. This Primer summarizes these developments and discusses the challenges ahead.
Huntington disease is an autosomal dominant neurological disorder caused by mutation in HTT. The disease typically manifests in adulthood and is characterized by progressive motor, cognitive and behavioural impairment. This Primer discusses the current knowledge of this disease.
Systemic sclerosis is an autoimmune disease characterized by vasculopathy-induced fibrosis of the skin and organs that can be life-threatening. Varga and colleagues describe the current views of pathogenesis and treatment, and present an outlook for the future.
Menopause is the age-related loss of female reproductive function. Here, Davis et al. describe menopause physiology and its impact on women's health. They call for more research to understand the basic biology underlying this transition and to develop new therapies.
