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The Ontario Brain Institute manages a network of partnerships among researchers, clinicians, industry representatives and patients to maximize their collective impact on developing better treatment and care for those living with brain disorders.
Pfizer, Eli Lilly, Janssen and Regeneron are advancing a promising class of analgesic drugs, hoping to put concerns around autonomic dysfunction and joint destruction behind them.
This analysis of changes in the length of clinical trials over time provides evidence of increased efficiency in drug development and investigates the possible contributing factors.
The balance between muscle contraction and relaxation is disrupted in various human diseases, including heart failure, cardiomyopathies, skeletal myopathies and neuromuscular conditions. Here, Hwang and Sykes discuss therapeutic strategies aimed at modulating the mechanical function of the sarcomere, focusing on agents that affect the function of myosin or the troponin complex.
Hydrogen sulfide (H2S) is a ubiquitous gaseous signalling molecule with a plethora of important roles. In this Review, Wallace and Wang describe the pathways for the synthesis and metabolism of H2S and its major mechanisms of action in health and in disease processes, before discussing examples of attempts to exploit the actions of H2S in the design of novel drugs.
Hearing loss, which is caused by both genetic and environmental factors, is the most common form of sensory impairment in humans. Current treatment relies on medical devices and there are no drug-based therapies available. Here, Müller and Barr-Gillespie review the various forms of hearing loss, highlight emerging pharmacological targets and discuss the potential of regenerative medicine and gene therapy to restore auditory function.
