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The efficiency and effectiveness of target selection and validation could be improved with accessible, standardized and integrated biological reference data sets. Such resources should be established through precompetitive approaches.
Grabowski and colleagues analyse the European market uptake of biosimilar versions of two major therapeutic biologics — epoetin alfa and filgrastim — and discuss the implications for the future development of the market for biosimilars.
Ligand efficiency metrics quantify the molecular properties required to gain binding affinity for a drug target. This article discusses the application of such metrics in the selection and optimization of fragments, hits and leads, highlighting how optimizing ligand efficiency metrics based on both molecular mass and lipophilicity, when set in the context of the specific target, has the potential to increase the quality of drug candidates.
Herpesviruses can hijack the G protein-coupled receptor (GPCR)-mediated cellular signalling networks of their host, which subverts cellular signalling and contributes to viral pathogenesis. In this Review, the authors discuss how herpesvirus-encoded GPCRs could be promising targets in certain inflammatory and proliferative diseases.
The activation of phosphoinositide 3-kinase (PI3K) signalling is nearly ubiquitous in human cancer, but inhibitors of this pathway have demonstrated only limited activity in the clinic. Here, Fruman and Rommel discuss the complexity of the PI3K signalling network in cancer, address challenges associated with therapeutic intervention and propose strategies to guide future efforts in translational and clinical research.
