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Modern biomedical research: an internally self-consistent universe with little contact with medical reality?

Nature Reviews Drug Discovery volume 2, pages 151–154 (2003)Cite this article

Abstract

Congruence between in vitro and animal models of disease and the corresponding human condition is a fundamental assumption of much biomedical research, but it is one that is rarely critically assessed. In the absence of such critical assessment, the assumption of congruence may be invalid for most models. Much more open discussion of this issue is required if biomedical research is to be clinically productive.

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Figure 1: Hesse's The Glass Bead Game.

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  1. Laxdale Ltd, Kings Park House, Laurelhill Business Park, Stirling, FK7 9JQ, Scotland

    David F. Horrobin

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  1. David F. Horrobin
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FURTHER INFORMATION

US Food and Drug Administration

European Medicines Evaluation Agency

Enclycopedia of Life Sciences

Human disease: mouse models

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Horrobin, D. Modern biomedical research: an internally self-consistent universe with little contact with medical reality?. Nat Rev Drug Discov 2, 151–154 (2003). https://doi.org/10.1038/nrd1012

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