Although CpG oligodeoxynucleotides (ODNs) are useful vaccine adjuvants, optimizing these single-stranded synthetic DNAs to induce the desired immune response is tricky. This paper showed that K-class ODNs could be multimerized into stable nanorings using the HIV-derived peptide Tat. In mice, the nanorings boosted T helper 1 cell-mediated immune responses to a viral antigen, and produced good antitumour immunity when used as a therapeutic tumour vaccine adjuvant. So such ODN nanorings could be used as improved anticancer or antiviral vaccine adjuvants.
References
Gungor, B. et al. CpG ODN nanorings induce IFNα from plasmacytoid dendritic cells and demonstrate potent vaccine adjuvant activity. Sci. Transl. Med. 6, 235ra61 (2014)
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Harrison, C. Nanorings boost vaccine adjuvant effects. Nat Rev Drug Discov 13, 496 (2014). https://doi.org/10.1038/nrd4380
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DOI: https://doi.org/10.1038/nrd4380
