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Isothermal titration calorimetry can be used to obtain thermodynamic data on the binding of compounds to protein targets. Ladbury and colleagues propose that these data — particularly the change in enthalpy — could be a valuable addition to established tools for selecting compounds in lead discovery and for aiding lead optimization.
The complement system has long been known to have a pathogenic role in various disorders, but the therapeutic potential of modulating complement responses has only recently been recognized. In this article, Wagner and Frank review those diseases associated with complement activation and deregulation and focus on promising therapeutic strategies and agents that are currently in the clinic.
The Commissioner for Patents at the United States Patent and Trademark Office discusses the challenges that he faces as he takes up his new appointment.
Establishing a common language for the stakeholders in stratified medicine — including drug developers, diagnostic companies, regulators and payers — could help tackle the complex challenges posed by biomarker-based drug development.