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The overuse of opioids for acute pain management has led to an epidemic of persistent opioid use. A new study by Brown and colleagues evaluates opioids prescribed at discharge from hospital after coronary artery bypass graft surgery and heart valve procedures.
Salt substitutes hold great potential for the control of blood pressure and prevention of chronic disease, but the evidence base remains inadequate. Data from a community-based trial in Peru add to this evidence base and support the conduct of large-scale trials to drive the global uptake of salt substitution.
In the decade after the introduction of Impella heart pumps, their use has rapidly increased. However, to date, clinical trial data have not conclusively supported their superiority over other contemporary support devices, and observational experiences have identified signals of increased harm with Impella. Large, adequately powered clinical trials of Impella are eagerly awaited.
