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Relationships between atrial fibrillation and obesity, sleep apnea and C-reactive protein have only recently been recognized. In this case, an obese patient with a history of atrial fibrillation was diagnosed with concomitant sleep apnea and elevated C-reactive protein. Having exhausted various possibilities of cardiological intervention and seemingly destined for catheter-based pulmonary vein isolation, the patient finally achieved rhythm control through weight loss. This study illustrates linkage of these conditions, discussing current therapeutic options and exploring possible pathophysiologic connections.