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Extravascular implantable cardioverter–defibrillators are safe and effective at detecting and terminating ventricular arrhythmias induced at the time of implantation.
An invitation to undergo comprehensive cardiovascular screening in men aged 65–74 years did not lower the incidence of death from any cause after 5 years in the DANCAVAS trial, but data suggest benefits in some outcomes and in reducing mortality in men aged < 70 years.
Haematopoietic mosaic loss of the Y chromosome, a phenomenon that frequently occurs with age, directly contributes to cardiac fibrosis and dysfunction.
In a new mouse model of spontaneous ventricular tachycardia after myocardial infarction, cardiac neutrophils increased the likelihood of arrhythmia, whereas cardiac macrophages protected against arrhythmia.
Overexpression of a circular RNA derived from the gene encoding the insulin receptor (Circ-INSR) prevents the development of cardiac dysfunction that occurs in response to anti-cancer therapy with doxorubicin.
Transient inhibition of the glucocorticoid receptor promotes cardiomyocyte proliferation and heart regeneration after myocardial infarction in the adult mouse heart.
Meteorin-like protein acts on endothelial cells through the receptor KIT to promote angiogenesis and reduce scar formation after myocardial infarction.
Two new papers describe the transcriptional programmes of congenital heart disease and dilated and hypertrophic cardiomyopathy assessed using single-nucleus RNA-sequencing technologies.
Activating the serine biosynthesis pathway might be a potential strategy for the treatment of dilated cardiomyopathy, according to a phenotypic screening study.
High plasma levels of HDL cholesterol have been shown to be associated with a lower risk of cardiovascular disease. However, paradoxically, very high HDL-cholesterol levels are associated with increased mortality in patients with coronary artery disease, according to a new study.
The stretch-activated, calcium-permeable Piezo1 channel is the mechanosensor that transduces cardiomyocyte stretch into the biochemical signalling pathway that leads to cardiac hypertrophy in mice.
Adding remnant cholesterol levels to traditional risk scores for ischaemic heart disease and myocardial infarction improves the accuracy of individual risk stratification.
The cardiac parasympathetic nervous system is composed of two parallel circuits with distinct functions: one selectively controls cardiac function and another coordinates cardiac and pulmonary function.
Different Notch ligands have opposing roles in regulating the proliferation and differentiation of vascular smooth muscle cells in the pulmonary vasculature in pulmonary arterial hypertension. Selectively targeting Jagged 1–NOTCH3 signalling might be an effective and safe strategy for the treatment of this condition.
Dietary interventions can reduce the risk of cardiovascular events. According to the CORDIOPREV study, a Mediterranean-style diet is superior to a low-fat diet in preventing major cardiovascular events in patients with cardiovascular disease.
The soybean flavonoid genistein can attenuate cannabis-induced inflammation, oxidative stress and atherosclerosis by binding to and inhibiting cannabinoid receptor 1.