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Inhibition of fatty acid metabolism to promote oxidation of glycolysis-derived pyruvate promotes cardiomyocyte proliferation and improves left ventricular function after myocardial infarction.
A study published in Nature identifies the semaphorin receptor plexin D1 as a novel mechanoreceptor in endothelial cells that regulates vascular function and the site-specific distribution of atherosclerosis.
Macrophages directly contribute collagen to scar formation as part of heart regeneration in zebrafish and heart repair in mice; this finding develops the current paradigm of collagen deposition for scar formation being generated exclusively via macrophage-mediated activation of cardiac fibroblasts to myofibroblasts.
D6PV, a dual apolipoprotein C-II mimetic and apolipoprotein C-III antagonist, increases triglyceride lipolysis in mouse models of hypertriglyceridaemia.
A somatic gene editing therapy for the treatment of Duchenne muscular dystrophy (DMD) improves skeletal and cardiac muscle function and reduces cardiac arrhythmogenic vulnerability in a pig model of DMD and an in vitro model of human DMD.
Long QT syndrome (LQTS) is the most common inherited cardiac arrhythmia and has been associated with mutations in 17 different genes; however, the evidence that many of these genes are actually causative for LQTS is limited or disputed.
Autologous mitochondrial transplantation for myocardial protection is feasible, safe and beneficial; however, the mechanisms by which these effects are achieved are uncertain.
