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As yet, 22 cases of short QT syndrome have been confirmed but other cases have probably been overlooked. This syndrome is a heritable primary electrical disease of the heart that can lead to atrial fibrillation and sudden cardiac death. The knowledge to date on this little recognized disorder is presented.
Congestive heart failure and chronic kidney disease are severe diseases, but a frequently complicated individually by anemia. If all three disorders are present, a vicious circle ensues, in which each component causes or worsens the other two. This review discusses the inter-relationships and how to approach correction or alleviation of this syndrome.
Although a number of therapies have been able to reduce infarct size as part of reperfusion therapy in experimental studies, the clinical results after acute myocardial infarction have not been as satisfactory. Current understanding of the mechanisms and consequences of reperfusion injury and the pharmacologic options are discussed here.