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A protocol extension describing the purification of prenatal human brain endothelial and mural cells with FACS and their utilization in downstream applications, including cell culture, organoid transplantation and single-cell transcriptomics.
This Protocol Extension combines optogenetics with juxtacellular recordings and describes procedures for targeting, recording and labeling individual genetically defined neurons in freely moving mice.
This Protocol Extension describes Zebrafish targeting of Reactive Electrophiles and oXidants (Z-REX), an extension of a Protocol on the targetable reactive electrophiles and oxidants, adapted for on-demand redox targeting in live zebrafish embryos. The protocol details how to generate transgenic fish and run Z-REX, as well as its downstream validation.
This Protocol Extension describes an operant model in which mice lever press to obtain rewarding social interaction with a peer. The model can be used to study the role of operant social reward and other neuropsychiatric disorders with a component of social dysfunction.
This Protocol Extension presents an updated tetrahedral DNA nanostructure for the delivery of various bioactive molecules that enables an active targeting strategy to be used for stimuli-sensitive conformation changes and on-site cargo release.