Abstract
The effects of acute, systemic administration of the putative atypical antipsychotic drug amperozide on c-fos expression in the rat forebrain were studied by means of Fos immunohistochemistry. Amperozide significantly increased the number of Fos-immunoreactive nuclei in the medial prefrontal cortex and the lateral septum but not in the nucleus accumbens (shell or core), the striatum, or the amygdala. With the exception of the nucleus accumbens-shell, where amperozide failed to produce statistically significant increases, the regional distribution of Fos immunoreactivity following amperozide was similar to that induced by atypical, but not by typical, antipsychotic drugs. In addition, after amperozide the number of Fos-positive nuclei was higher in the nucleus accumbens than in the dorsolateral striatum, a characteristic that is common to all known atypical antipsychotic agents.
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Acknowledgements
This work was supported by the Swedish Medical Research Council (projects 04747 and 11026), the Swedish Society of Medicine, the Karolinska Institute, and LEO’s Research Foundation and Janssen Pharmaceutica, Beerse, Belgium. The authors thank Mrs. Anna Malmerfelt for help with the counting of cells and for preparing the photomicrographs.
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Nomikos, G., Tham, CS., Fibiger, H. et al. The Putative Atypical Antipsychotic Drug Amperozide Preferentially Increases c-fos Expression in Rat Medial Prefrontal Cortex and Lateral Septum. Neuropsychopharmacol 17, 197–201 (1997). https://doi.org/10.1016/S0893-133X(97)00041-9
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DOI: https://doi.org/10.1016/S0893-133X(97)00041-9