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To determine the physiologically relevant oligomeric form of membrane proteins is extremely challenging. Now an elegant method of counting the oligomers in membrane proteins in near-native states is presented, using photobleaching and nanodiscs formed directly from cellular membranes.
In a major advancement for synthetic biology, dynamin A has been identified as a minimal component enabling cell division in synthetic cells, moving us one step nearer to realizing the ambition of creating synthetic life forms.
DNA-origami nanostructures self-assembled at milder physicochemical parameters in magnesium-free conditions achieve structural complexities akin to those formed by thermal annealing at elevated temperatures, and open a route to assembling DNA nanomachines in physiological conditions.
By integrating a 3D nanopositioner with a solid-state nanopore and surface-tethered molecules, precise spatiotemporal control over single DNA strands is achieved, enabling numerous re-reads and raising the signal-to-noise ratio far beyond previous solid-state nanopore methods.
Integration of diverse techniques for in-plane electrokinetic control of a functionalized gold nanowire’s position and orientation enables applications in nanoscale manipulation, nano-assembly, and single-cell biochemical sensing.
A Berry curvature dipole can be generated at certain symmetry-mismatched van der Waals hetero-interfaces even though each material has no Berry curvature dipole in its band structure.