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Small interfering RNAs (siRNAs) can turn off any specific gene in the genome. As a result, these molecules have tremendous potential as both scientific tools and therapeutics. However, delivering siRNA to the right cells in vivo has remained challenging. Using combinatorial chemical synthesis techniques and high-throughput biological screening methods, Daniel Anderson and co-workers have designed a nanoparticle that delivers siRNA to endothelial cells cells that line blood and lymphatic vessels at very low doses. Using this nanoparticle, the researchers turned off five genes at once inside an animal, turned off genes for more than three weeks after one injection, and reduced inflammation, tumour growth and metastasis. The cover image shows blood vessels in mouse adipose tissue stained with two endothelial cell markers, CD31 (blue) and ICAM-2 (magenta).
This is the International Year of Crystallography and is a time to reflect on the success of the discipline. Looking ahead the field is well placed to produce further exciting contributions to science.
DNA nanotechnology has proven to be a powerful approach for fabricating active nanostructures with biological functionality. Now, it is time to investigate more solutions from biology to downscale robotics, says Christian Martin.
A polymer–lipid nanoparticle with a low molecular weight can preferentially deliver small interfering RNA to endothelial cells, offering an opportunity to treat many diseases.
Electrical signals can be used to assemble and tune enzymes, resulting in controlled levels of optically, electrochemically and biologically active products.
A half-cell lithium metal battery can cycle with good efficiency at relatively high current density by engineering a nanostructured surface between the negative electrode and the electrolyte.
Ultrafast, coherent spin dynamics in semiconductor heterostructures can be measured with a scanning tunnelling microscope by using femtosecond pulses of circularly polarized light.
This article reviews the fundamentals and applications of scanning probe lithography, focusing on the methods that offer genuinely lithographic capabilities such as those based on thermal effects, chemical reactions and voltage-induced processes.
Spin dynamics in semiconductor heterostructures can be probed by a modified scanning tunnelling microscopy technique with a temporal resolution of a few picoseconds.
The ensemble of massless electrons in graphene shows a collective non-zero inertia that can be measured by measuring the kinetic inductance of an encapsulated graphene device.
Hollow carbon nanospheres form a stable solid electrolyte interphase on lithium metal anodes that suppresses dendrite growth and improves cycling Coulombic efficiency.
Trapping of single HIV virions by optical tweezers reveals substantial heterogeneity in the numbers of envelope glycoproteins, which could have important consequences for infection and transmission.
Nanoparticles with high near-infrared absorption that transit the gut without being absorbed can be used for gastrointestinal imaging using photoacoustic and positron emission tomography.
Willingness to ask questions and having frank conversations with your collaborators can lead to many opportunities in translational research, reflects James E. Dahlman.