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Volume 9 Issue 8, August 2014

Small interfering RNAs (siRNAs) can turn off any specific gene in the genome. As a result, these molecules have tremendous potential as both scientific tools and therapeutics. However, delivering siRNA to the right cells in vivo has remained challenging. Using combinatorial chemical synthesis techniques and high-throughput biological screening methods, Daniel Anderson and co-workers have designed a nanoparticle that delivers siRNA to endothelial cells — cells that line blood and lymphatic vessels — at very low doses. Using this nanoparticle, the researchers turned off five genes at once inside an animal, turned off genes for more than three weeks after one injection, and reduced inflammation, tumour growth and metastasis. The cover image shows blood vessels in mouse adipose tissue stained with two endothelial cell markers, CD31 (blue) and ICAM-2 (magenta).

Article p648; News & Views p568; In the Classroom p656

IMAGE: AUDE THIRIOT

COVER DESIGN: ALEX WING

Editorial

  • This is the International Year of Crystallography and is a time to reflect on the success of the discipline. Looking ahead the field is well placed to produce further exciting contributions to science.

    Editorial

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Thesis

  • DNA nanotechnology has proven to be a powerful approach for fabricating active nanostructures with biological functionality. Now, it is time to investigate more solutions from biology to downscale robotics, says Christian Martin.

    • Christian Martin
    Thesis
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Research Highlights

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News & Views

  • A polymer–lipid nanoparticle with a low molecular weight can preferentially deliver small interfering RNA to endothelial cells, offering an opportunity to treat many diseases.

    • Daniel T. W. Clarke
    • Nigel A. J. McMillan
    News & Views
  • Naphthalocyanine nanoparticles offer intense photoacoustic signals for mapping the gastrointestinal tract.

    • Jesse V. Jokerst
    News & Views
  • Electrical signals can be used to assemble and tune enzymes, resulting in controlled levels of optically, electrochemically and biologically active products.

    • Gretchen Mahler
    News & Views
  • A half-cell lithium metal battery can cycle with good efficiency at relatively high current density by engineering a nanostructured surface between the negative electrode and the electrolyte.

    • Renaud Bouchet
    News & Views
  • Ultrafast, coherent spin dynamics in semiconductor heterostructures can be measured with a scanning tunnelling microscope by using femtosecond pulses of circularly polarized light.

    • Sebastian Loth
    • Jacob A. J. Burgess
    • Shichao Yan
    News & Views
  • Massless electrons in graphene exhibit a mass when considered as collective excitations known as plasmons.

    • Fengnian Xia
    News & Views
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Review Article

  • This article reviews the fundamentals and applications of scanning probe lithography, focusing on the methods that offer genuinely lithographic capabilities such as those based on thermal effects, chemical reactions and voltage-induced processes.

    • Ricardo Garcia
    • Armin W. Knoll
    • Elisa Riedo
    Review Article
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Letter

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Article

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In the Classroom

  • Willingness to ask questions and having frank conversations with your collaborators can lead to many opportunities in translational research, reflects James E. Dahlman.

    • James E. Dahlman
    In the Classroom
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