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Volume 10 Issue 8, August 2015

In rod-shaped Escherichia coli cells, Min proteins oscillate back and forth between poles to assist cell division. Cees Dekker and colleagues have now been able to explore how these proteins adapt to different cellular geometries by using nanofabricated chambers to ‘sculpt’ living bacterial cells into a variety of shapes and sizes. The cells are shaped into squares, rectangles, circles and triangles, and the Min proteins exhibit a range of versatile oscillation patterns that include rotational, longitudinal, diagonal, stripe and transversal modes. The data demonstrate how a Turing reaction–diffusion process achieves adaptation within the cell boundary. The artist’s impression on the cover shows bacterial cells sculpted into a variety of shapes, and highlights the oscillating patterns of Min proteins experimentally observed within such shaped cells.

Article p719; News & Views p655

IMAGE: CEES DEKKER LAB, TU DELFT / TREMANI

COVER DESIGN: KAREN MOORE

Research Highlights

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News & Views

  • Bacterial cells can be sculpted into different shapes using nanofabricated chambers and then used to explore the spatial adaptation of protein oscillations that play an important role in cell division.

    • Kerwyn Casey Huang
    News & Views
  • Synthetic muscles built from DNA nanotube scaffolds can be used to study how myosin motors work together to make real muscles function.

    • Edward P. Debold
    News & Views
  • Molecular dynamics simulations show that the flow of water through carbon nanotubes can be enhanced by exciting the phonon modes of the nanotube.

    • Lydéric Bocquet
    • Roland R. Netz
    News & Views
  • On bending, nanowires display anelastic behaviour, recovering their initial shape over time and efficiently dissipating mechanical energy in the process.

    • Daniel S. Gianola
    • Jungho Shin
    News & Views
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Correction

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Letter

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Article

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In the Classroom

  • Interacting with 3D-printed molecular models helps students to grasp insightful concepts on the kinetics and thermodynamics of molecular self-assembly, as Arthur J. Olson explains.

    • Arthur J. Olson
    In the Classroom
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