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Volume 9 Issue 2, February 2024

Visualizing Tc toxin release

This image shows type 10 secretion system (T10SS)-mediated Tc toxin release by Yersinia entomophaga, as captured by cryo-electron tomography. Spanin-mediated membrane fusion triggers bacterial lysis and the explosive discharge of pre-assembled toxins by a subset of the bacterial population.

See Sitsel et al.

Credit: Oleg Sitsel and Stefan Raunser, Max Planck Institute of Molecular Physiology. Cover design: Valentina Monaco

Editorial

  • Mentorship can be invaluable to a research career, but more guidance is needed to ensure effective mentor–mentee relationships.

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Comment & Opinion

  • Training and funding for mentoring, together with metrics to measure success, can ensure this vital practice is beneficial for all mentees, at all stages of their career, argues Michal Elovitz.

    • Michal A. Elovitz
    World View
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Research Highlights

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Comment & Opinion

  • Philip Poole narrates his career story and his motivations for studying rhizobia, the agriculturally important bacterial plant symbiont responsible for fixing nitrogen.

    • Philip Poole
    Microbe Matters
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News & Views

  • Metabolomics and feeding experiments demonstrate the host’s active role in sharing organic acids with a gut microbiota member, revealing host–microbe interactions that foster symbiosis.

    • Dolma Michellod
    • Manuel Liebeke
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Research Briefings

  • Cases of Buruli ulcer in southeastern Australia have increased over the past 10 years. Native possums are a reservoir for Mycobacterium ulcerans (the cause of Buruli ulcer), but the route of transmission to humans is unclear. Our findings identify mosquitoes as the vector of M. ulcerans from possums to humans.

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