Volume 2 Issue 9 September 2017

Volume 2 Issue 9

Going straight

Growth of Escherichia coli in curved micro-channels that forced them to grow to a deformed shape, followed by release to allow a return to native form suggests that E. coli utilize mechanical stresses as cues for shape recovery.

See Wong, F, et al2, 17115 (2017)

Image: Equinox Graphics, Cover Design: Karen Moore

Editorial

  • Editorial |

    The recommendation that antibiotic courses are always completed should be dropped according to a recent analysis. While a welcome addition to discussion on the role of stewardship in tackling resistance, caution should be applied before advice on prescription practices and communication with patients is altered.

News and Views

  • News and Views |

    The 2013–2016 West African Ebola virus outbreak evidenced that the virus can persist in survivors long-term, leading to sequelae and risks of new transmission chains. Ebola virus has now been shown to behave similarly in rhesus macaques, enabling their use to study persistence and intervention strategies.

    • Trina Racine
    •  & Gary P. Kobinger
  • News and Views |

    Structural analyses of the type IV coupling protein of the Dot/Icm type IV secretion system from Legionella pneumophila reveal how this platform recruits a plethora of substrates for translocation.

    • Peter J. Christie
  • News and Views |

    Proteomics analyses reveal how the long-term coexistence of the marine picocyanobacterium Synechococcus and the heterotroph Ruegeria pomeroyi, of the globally abundant marine Roseobacter group, is based on the mutual and beneficial recycling of inorganic and organic nitrogen compounds.

    • Meinhard Simon

Review and Perspective

Research

  • Article |

    In situ analysis of natural Crocosphaera populations revealed diel cycling of transcript abundances for a range of metabolic pathways, indicating that these cyanobacteria are dominant nitrogen fixers and contributors to primary productivity.

    • Samuel T. Wilson
    • , Frank O. Aylward
    • , Francois Ribalet
    • , Benedetto Barone
    • , John R. Casey
    • , Paige E. Connell
    • , John M. Eppley
    • , Sara Ferrón
    • , Jessica N. Fitzsimmons
    • , Christopher T. Hayes
    • , Anna E. Romano
    • , Kendra A. Turk-Kubo
    • , Alice Vislova
    • , E. Virginia Armbrust
    • , David A. Caron
    • , Matthew J. Church
    • , Jonathan P. Zehr
    • , David M. Karl
    •  & Edward F. DeLong
  • Article |

    A structural analysis of the C-terminal extension of DotL and its binding partners DotN, IcmS, IcmW and LvgA elucidates how the type IV secretion system (T4SS) of Legionella pneumophila mediates the recruitment of T4SS effectors.

    • Mi-Jeong Kwak
    • , J. Dongun Kim
    • , Hyunmin Kim
    • , Cheolhee Kim
    • , James W. Bowman
    • , Seonghoon Kim
    • , Keehyoung Joo
    • , Jooyoung Lee
    • , Kyeong Sik Jin
    • , Yeon-Gil Kim
    • , Nam Ki Lee
    • , Jae U. Jung
    •  & Byung-Ha Oh
  • Article |

    A lack of models has hindered the study of Ebola virus (EBOV) persistence and sequelae, which are now shown to occur in rhesus monkeys. Progressive EBOV spread into eyes, brain and testes with CD68+ cells as the cryptic EBOV reservoir.

    • Xiankun Zeng
    • , Candace D. Blancett
    • , Keith A. Koistinen
    • , Christopher W. Schellhase
    • , Jeremy J. Bearss
    • , Sheli R. Radoshitzky
    • , Shelley P. Honnold
    • , Taylor B. Chance
    • , Travis K. Warren
    • , Jeffrey W. Froude
    • , Kathleen A. Cashman
    • , John M. Dye
    • , Sina Bavari
    • , Gustavo Palacios
    • , Jens H. Kuhn
    •  & Mei G. Sun
  • Letter |

    Whether phage genetic mosaicism generates a spectrum of diversity or discrete populations is unclear. Two phage evolutionary modes are described here that differ in the extent of horizontal gene transfer depending on host, lifestyle and genetic constitution

    • Travis N. Mavrich
    •  & Graham F. Hatfull
  • Letter |

    This study reports the structure of hRSV NS1, identifying unique regions that modulate host gene expression and contribute to inhibition of the IFN-I pathway and of dendritic cell maturation, pointing to new avenues of hRSV attenuation.

    • Srirupa Chatterjee
    • , Priya Luthra
    • , Ekaterina Esaulova
    • , Eugene Agapov
    • , Benjamin C. Yen
    • , Dominika M. Borek
    • , Megan R. Edwards
    • , Anuradha Mittal
    • , David S. Jordan
    • , Parameshwar Ramanan
    • , Martin L. Moore
    • , Rohit V. Pappu
    • , Michael J. Holtzman
    • , Maxim N. Artyomov
    • , Christopher F. Basler
    • , Gaya K. Amarasinghe
    •  & Daisy W. Leung
  • Article |

    Development of a broad-spectrum β-lactamase inhibitor capable of combatting multidrug-resistant pathogens, including Acinetobacter baumannii.

    • Thomas F. Durand-Réville
    • , Satenig Guler
    • , Janelle Comita-Prevoir
    • , Brendan Chen
    • , Neil Bifulco
    • , Hoan Huynh
    • , Sushmita Lahiri
    • , Adam B. Shapiro
    • , Sarah M. McLeod
    • , Nicole M. Carter
    • , Samir H. Moussa
    • , Camilo Velez-Vega
    • , Nelson B. Olivier
    • , Robert McLaughlin
    • , Ning Gao
    • , Jason Thresher
    • , Tiffany Palmer
    • , Beth Andrews
    • , Robert A. Giacobbe
    • , Joseph V. Newman
    • , David E. Ehmann
    • , Boudewijn de Jonge
    • , John O'Donnell
    • , John P. Mueller
    • , Rubén A. Tommasi
    •  & Alita A. Miller
  • Letter |

    The undulating surface of mycobacterial cells contains wave troughs inherited from the (grand)mother cell that, combined with chromosome positioning, determine the site where cell division takes place.

    • Haig A. Eskandarian
    • , Pascal D. Odermatt
    • , Joëlle X. Y. Ven
    • , Mélanie T. M. Hannebelle
    • , Adrian P. Nievergelt
    • , Neeraj Dhar
    • , John D. McKinney
    •  & Georg E. Fantner
  • Letter |

    Metabolic labelling can be used to simultaneously tag peptidoglycan, lipopolysaccharide and capsular polysaccharide of live gut bacteria, and to label peptidoglycan in vivo, revealing host–bacteria interactions within the living mammalian host.

    • Jason E. Hudak
    • , David Alvarez
    • , Ashwin Skelly
    • , Ulrich H. von Andrian
    •  & Dennis L. Kasper
  • Article |

    Structural analysis of the type VI secretion TssK baseplate protein shows structural similarities with phage receptor-binding protein.

    • Van Son Nguyen
    • , Laureen Logger
    • , Silvia Spinelli
    • , Pierre Legrand
    • , Thi Thanh Huyen Pham
    • , Thi Trang Nhung Trinh
    • , Yassine Cherrak
    • , Abdelrahim Zoued
    • , Aline Desmyter
    • , Eric Durand
    • , Alain Roussel
    • , Christine Kellenberger
    • , Eric Cascales
    •  & Christian Cambillau

Amendments and Corrections