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Prokaryotic RNA viruses recovered from hot springs in Japan using fragmented and primer-ligated dsRNA sequencing form divergent clades in the Riboviria branch of RNA viruses.
The gut commensal Christensenalla minuta produces a previously undescribed class of secondary bile acids that counteract features of metabolic disease and are depleted in patients with type 2 diabetes.
Enrichments from bioreactors find a single bacterium capable of methane oxidation coupled to nitrate reduction via nitrite to dinitrogen, a process previously thought to rely on syntrophy.
Characterization of quorum sensing-regulated antibiotic production by Streptococcus salivarus and signal eavesdropping by Streptococcus pyogenes enables engineering of a probiotic strain to prevent pathogen signal eavesdropping and antibiotic degradation, and inhibit colonization.
Brain glucose induces in vivo tolerance of Cryptococcus neoformans to amphotericin B, limiting fungicidal efficacy against meningitis in a mouse model, and aureobasidin A inhibits brain glucose-induced tolerance, improving therapeutic outcome.
Comparative metabolomics and NanoSIMs reveal that the honey bee symbiont Snodgrassella alvi uses host-derived metabolites to colonize the gut, indicating adaptation to a specific metabolic niche in its host.
A diverse arsenal of fibre-like proteins extend outward from the B. bacteriovorus cell surface and localize towards prey cells, facilitating recognition and invasion.
The phage-encoded arbitrium communication system controls the activity of the host bacterial toxin–antitoxin system MazE–MazF to regulate lysis–lysogeny decision.
Three distinct families of gut bacteria encode an unprecedented number of respiratory-like reductases per genome to perform anaerobic respiration of biomedically relevant substrates.
Using proximity labelling and single-particle tracking super-resolution microscopy, this study illuminates the initial steps of type III secretion and the path of T3SS effectors before their translocation into target cells.
Computational analyses and molecular genetics reveal that integron cassettes integrate into bacterial genomes at widespread non-classical attG sites, enabling acquisition of genetic material and disruption of existing genes with potential consequences for bacterial evolution.
Opportunistic plant pathogen Xanthomonas secretes leaf-degrading enzymes through the type-2 secretion systems that cause disease and thereby trigger changes in leaf microbiome composition.
PRO-seq, which does not need antibodies or epitope tags on RNAP, is adapted to report nascent transcription in bacteria including human gut microbiome samples.
High-throughput growth assays show that cyclic-oligonucleotide-based anti-phage signalling systems modulate Vibrio cholerae sensitivity to antifolates, and ultimately trigger cell lysis by these drugs.
Bacteroides fragilis toxin expression induces goblet cell and goblet-cell-associated passage development during the pre-weaning period in mice, enabling B. fragilis to access a privileged lamina propria niche and evade competition with gut lumen bacteria.
This work reveals a mechanism of cGAS- and STING-dependent type I IFN induction in response to biofilm-associated Candida albicans DNA packaged in extracellular vesicles.