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This Review summarizes sixteen known co-produced bacterial metabolites, their biosynthesis strategies and their synergistic antimicrobial activity mechanisms.
Transposon directed insertion–site sequencing (TraDIS) is used to identify T6SS toxins in Pseudomonas aeruginosa, leading to the discovery of Tse8 as a protein that is delivered to target cells where it alters the stoichiometry of the transamidosome complex and thereby inhibits protein synthesis.
Roots of different plant species are colonized by distinct microbiota, even when grown in the same soil. A comprehensive combination of experimental manipulation of plant species, plant mutations, plant signalling, community composition and order of community application reveals how community assembly differs among plant species.
Evolution of the SARS-CoV-2 spike protein receptor-binding domain in vitro recapitulates SARS-CoV-2 variant emergence and produces an effective antiviral spike receptor-binding domain variant.
Malaria parasites are protected from febrile temperatures in humans by a heat-shock response that is coordinated by the transcriptional activator PfAP2-HS.
To grow and divide properly, bacteria need to coordinate DNA replication with cell division. A recent study identifies CcrZ as a protein from Streptococcus pneumoniae that links these two processes by interacting with FtsZ, the orchestrator of cell division, and modulating the activity of DnaA, the initiator of DNA replication.
In this Article, the authors identify CcrZ as a protein that coordinates DNA replication and cell division in Streptococcus pneumoniae and other Firmicutes. CcrZ is localized to the division site by binding directly to the divisome protein FtsZ, and there it activates DnaA, the master initiator of DNA replication, through a still unknown mechanism.
Experimental evolution of persistence during Mycobacterium canettii infections of mice sheds light on the origins of virulence in ancestral Mycobacterium tuberculosis.
Quiescent fungal conidia are heterogeneous and prepare for the future through transcriptional programmes that depend on the environment in which the conidia develop.
Host preferences of commensal bacteria in the root microbiota are revealed using systematic analyses of synthetic bacterial communities in a gnotobiotic system.
In vivo experimental evolution of Mycobacterium canettii populations reveals enhanced persistence of evolved mutants due to resistance to host-derived stresses, providing insight into the emergence of persistent Mycobacterium tuberculosis.
Longitudinal tracing of antibody responses to the ChAdOx1 and the BNT162b2 COVID-19 vaccines in 45,965 adults from the United Kingdom give indications for vaccine prioritization.