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During archaeal cell division, proteins containing photosynthetic reaction centre domains enable the formation of a defined cell division plane by direct interaction with SepF.
Metabolic engineers and synthetic biologists can produce recombinant proteins at scale without royalty payments, or strain distribution constraints, using OPENPichia.
A set of computational tools to de novo recognize plasmids in complex environments, like the human gut microbiome, and to organize them into evolutionarily cohesive units.
Photosynthesis reaction centre barrel proteins are important components of the FtsZ-based cell division apparatus in Haloferax volcanii and other archaea.
Active hydrothermal vents are hotspots of life in the deep sea, but even after hot springs go extinct, highly productive microbial communities continue to thrive on the chemical energy in the minerals left behind.
Graft-versus-host disease, a T cell-driven inflammatory condition, is associated with altered microbial bile acid metabolism in both mice and humans and this is linked to outcomes.
A 5 year longitudinal, retrospective and multi-centre epidemiological study of carbapenem-resistant Klebsiella pneumoniae across China reveals antibiotic resistance, virulence gene and capsule profiles for 1,017 isolates showing increased K64 prevalence, increased hypervirulence and moderate frequency, stable circulation of capsule- or O-antigen-deficient strains.
Autophagy in CD11c+ phagocytes prevents myeloid-derived suppressor cell recruitment and promotes protective T cell responses during high-dose Mycobacterium tuberculosis infection in mice.
Bacteria cooperate by secreting siderophores that displace iron from the antibiotic cefiderocol, reducing drug uptake and promoting the cross-protection of susceptible siblings and other species.
The Candida albicans toxin, candidalysin, is embedded in an unusual conserved precursor peptide sequence (Ece1). The precursor is not required to block premature pore-forming toxicity, but rather to prevent candidalysin auto-aggregation.
Human norovirus infection is a major global health concern, but a suitable animal model is lacking. We have established repeated infection with human norovirus in rhesus macaques via oral challenge. Animals demonstrate virus shedding in the stool and subsequent serum antibody responses, and virus replication is detected in the small intestine.
A participatory research initiative generates actionable data on avian diseases in New York City, showcases how a community-based approach can tackle misinformation, and actively engages students from historically underrepresented communities in science, technology, engineering and maths.
Decomposer microbiomes are universal across cadavers regardless of environmental conditions, and they use complex cross-feeding and interkingdom interactions to break down organic matter.