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Almost twenty years after it was first linked to control of Mycobacterium tuberculosis in macrophages, autophagy retakes centre stage, as shown in murine models and human cells.
Microbiota-targeted interventions for malnutrition are under investigation, but complex illnesses associated with malnutrition, such as eating disorders, may not be straightforward to treat.
Evidence that bacterial infection shapes susceptibility to recurrent UTI via epigenetic memory shows that integrated approaches that consider host and pathogen are essential to develop effective treatments.
Characterization of the myotis bat morbillivirus shows that infection in human cells is restricted by innate immune responses in vitro and cross-neutralization by sera from measles, mumps and rubella vaccinees.
An artificial intelligence system called BacterAI uses laboratory robots to learn the logic of microbial metabolism. BacterAI plans experiments autonomously and does not require any prior knowledge.
The microbiota associated with the rice plant panicle can protect against fungal disease via modulating host leucine production and induction of apoptosis-like cell death in the pathogen.
Colistin-resistant bacteria require fatty acid synthesis to maintain cell envelope homeostasis; disrupting fatty acid biosynthesis leads to the remodelling of phospholipid composition and decreases the fluidity of the cell envelope. Inhibitors of fatty acid biosynthesis resensitize bacteria to colistin, allowing for the treatment of colistin-resistant bacterial infections in mice.
Diagnosis is the weakest aspect of tuberculosis (TB) care and control. We describe seven critical transitions that can close the massive TB diagnostic gap and enable TB programmes worldwide to recover from the pandemic setbacks.
The authors argue that the virome of the last eukaryotic common ancestor is bacterial, rather than archaeal, providing support for a syntrophic model of eukaryogenesis with two endosymbiosis events.
Inhibition of fatty acid biosynthesis re-sensitizes colistin-resistant clinically relevant bacteria in vivo by inducing stress responses and altering membrane composition.
The cryogenic electron microscopy structure of the Pseudomonas aeruginosa cell division complex and antibiotic drug target, FtsWIQBL, suggests a possible activation mechanism.
Sampling beneath the Ross Ice Shelf in Antarctica coupled to global sequencing datasets reveals an important but overlooked contributor to deep ocean carbon and sulfur cycles.
The autophagy receptor SHISA9 balances innate immune responses during viral infection by controlling the levels of inhibitor of nuclear factor κB kinase subunit epsilon to restrict pathogenic inflammation in the central nervous system.
Bladder epithelial cells exposed to uropathogenic Escherichia coli infection have long-lasting epigenetic modifications linked with inflammation that influence host susceptibility to subsequent infections.
Statins have anti-cancer effects that are modulated by the gut commensal Lactobacillus reuteri and the tryptophan metabolite, indole-3-lactic acid, in mice and humans.
Faecal metagenomics and serum metabolomics reveal compositional and functional alterations in the gut microbiota of women with anorexia nervosa, and faecal transplants could transfer an anorexia-associated phenotype to germ-free mice.