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Fc–Fc gamma receptor interactions and alveolar macrophages contribute to ancestral vaccine-induced control of infection with SARS-CoV-2 variants in mice.
Comparison of mucosal and systemic immunity after vaccination with the live-attenuated vaccine sCPD9, mRNA vaccine BNT162b2 or an adenovirus-vectored vaccine following SARS-CoV-2 challenge in hamsters.
ProBac-seq is a method that uses libraries of DNA probes and commercial microfluidics for single-cell RNA-seq, leveraged here to show heterogeneous gene expression in clonal bacterial cultures including variable toxin expression in an agricultural strain of Clostridium.
Detection of persistent replication-competent HIV in monocytes from virologically suppressed people with HIV indicates that monocytes have a role as a latent reservoir.
Bile salt hydrolases encoded by the gut microbiome shape the bile acid pool, including microbial conjugated bile acids, which impact Clostridioides difficile infection in the murine gut.
Enterovirus-infected cells are extruded from the apical surface of differentiated human colon organoids by a mechanical-force-dependent mechanism that preserves the uninfected host epithelium.
An uncultivated, aerobic chemolithotrophic Sulfurimonas species with a reduced genome is abundant across diverse, hydrogen-rich hydrothermal plumes in the deep ocean.
Fungi from the Neocallimastigomycetes taxonomic class break bonds in lignin during the anaerobic deconstruction of whole plant cell walls. This finding challenges the paradigm that only certain aerobic organisms break down lignin.
Characterization of a contractile injection system (CIS) in the Gram-positive multicellular model organism Streptomyces coelicolor finds that CIS mediate cell death in response to stress that impacts cellular development.
Stable isotope-labelled amino acid incorporation into proteins reveals that genetically homogeneous yeast colonies contain metabolically distinct subpopulations that cross-feed each other and are phenotypically diverse.
Deployment of some CRISPR-Cas systems stunts host growth by degrading all transcripts, but Listeria seeligeri reverses dormancy using restriction-modification-based phage DNA targeting.
Systems genetics reveals interactions between host and microbial phenotypes in the murine gut, including a role for Akkermansia muciniphila in the production of immunomodulatory ornithine lipids.
Single-cell imaging, metabolomics and modelling quantify metabolic exchanges between cyanobacteria and heterotrophic bacteria, showing transient nutritional exchanges facilitated by chemotaxis of the heterotroph.
Application of reprogrammed bacteriophage to functional metagenomics in clinically relevant bacterial strains improves identification of antibiotic resistance genes, including those against recently developed or approved antibiotics.