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Methods relying on dense arrays of synthetic oligodeoxynucleotides to target specific subsets of the human genome may enable routine resequencing of all human exons or multi-megabase-pair chromosomal regions.
An aspirin-modulated gene expression control circuit provides a powerful method to regulate expression of bacterial genes inside an infected host. This should provide a safe and easy way to study host-pathogen interactions, and may have direct therapeutic applications.
Scientists may have finally developed the techniques to reconstruct complete wiring diagrams for the neuronal circuitry of the human brain. Nathan Blow reports.
In the context of this month's global theme on poverty and human development, we are turning the spotlight to diagnostic methods—more specifically, tests for diagnosing infectious diseases in poverty-stricken areas.
Research performed where epidemics hit the hardest is necessary to bring solutions to the major health crises that plague poverty-stricken areas. Far from being limited to these areas, 'research in situ' can benefit health management worldwide. There are pressing technological needs to be addressed in order to facilitate such research.