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Single-image fluorescence lifetime imaging microscopy (siFLIM) uses a modulated-FLIM camera to record lifetimes in a single snapshot, allowing for photon-efficient and quantitative lifetime imaging of rapid cellular processes.
Improved sample preparation methods allow super-resolution imaging by expansion microscopy using endogenous fluorescent protein signal and conventional fluorescently labeled antibodies.
Principal component analysis on a subset of differentially methylated regions in a mixture of cell types is the basis of ReFACTor, a program to account for heterogeneity in epigenome-wide association studies (EWAS).
A method (and resource) demonstrating the mining of information from large-scale phosphoproteomics data sets is presented, allowing users to build targeted parallel reaction monitoring mass spectrometry assays to study phosphosites of interest.
Quantitative points accumulation in nanoscale topography (qPAINT) makes use of predictable binding kinetics between DNA-PAINT imager and docking strands to achieve accurate and precise counting of molecules in spatially unresolved complexes.
PanPhlAn detects strains and characterizes strain-specific gene content and activity within metagenomic and metatranscriptomic samples for microbial population analysis and epidemiology.
The TraCeR tool extracts full-length, paired T cell receptor sequences from single-cell RNA-sequencing data from T lymphocytes, enabling a combination of clonotype and functional analysis.
SuReSim software simulates single-molecule localization microscopy data for structures with known ground truth models to facilitate proper design, interpretation and validation of super-resolution imaging experiments.
A high-resolution, Orbitrap-based, native mass spectrometry approach allows the direct characterization of lipid, peptide and drug binding to intact membrane proteins.
This report describes an imaging and analysis platform enabling high-throughput single-molecule fluorescence investigations of fast, transient molecular recognition events.
Frame-projected independent-fiber photometry (FIP) enables the concurrent monitoring and manipulation of neural activity at multiple sites in the brains of freely behaving mice.
EpiGBS (epi-genotyping by sequencing) constructs de novo references using reduced representation bisulfite sequencing followed by variant calling and methylation detection.
High-field fMRI with single-vessel resolution allows one to decipher the contribution of different types of vessels to hemodynamic activity evoked by sensory or optogenetic stimulation in the rat brain.
Software able to assemble long synthetic reads from barcoded Illumina short-read technology improves the assembly of metagenomic data sets and analysis of the human genome.
GenomeSpace is an open-source, cloud-based interoperability platform that facilitates integrative genomic analyses, allowing users to transition seamlessly between a diverse and growing set of bioinformatics tools and data resources.
By testing potential sources of biological signal that drive population-level variation in single-cell gene expression, the PAGODA software enables cells to be characterized on the basis of multiple functionally relevant features such as cell type, signaling state and cell cycle state.
A computational approach for precisely identifying and characterizing the molecular stoichiometry of multi-proteoform complexes using native top-down mass spectrometry data is reported.
Parallel, genome-wide methylation and transcriptional profiling from a single cell (scM&T-seq) enables the discovery of associations between transcriptional and epigenetic variation.