Erin Dewalt

Method of the Year 2019: Single-cell multimodal omics analysis

Latest Research

  • Article |

    Phenotypic earth mover’s distance (PhEMD) facilitates the comparison of single-cell experimental conditions, each of which is a high-dimensional dataset, and identifies axes of variation among multicellular biospecimens.

    • William S. Chen
    • , Nevena Zivanovic
    • , David van Dijk
    • , Guy Wolf
    • , Bernd Bodenmiller
    •  & Smita Krishnaswamy
  • Article |

    Advances in MINFLUX nanoscopy enable multicolor imaging over large fields of view, bringing true nanometer-scale fluorescence imaging to labeled structures in fixed and living cells.

    • Klaus C. Gwosch
    • , Jasmin K. Pape
    • , Francisco Balzarotti
    • , Philipp Hoess
    • , Jan Ellenberg
    • , Jonas Ries
    •  & Stefan W. Hell
  • Article |

    4Pi single-molecule switching microscopy combined with ‘salvaged fluorescence’ enables improved ratiometric imaging that bypasses chromatic aberrations and allows for multicolor whole-cell imaging with sub-10-nm localization precision.

    • Yongdeng Zhang
    • , Lena K. Schroeder
    • , Mark D. Lessard
    • , Phylicia Kidd
    • , Jeeyun Chung
    • , Yuanbin Song
    • , Lorena Benedetti
    • , Yiming Li
    • , Jonas Ries
    • , Jonathan B. Grimm
    • , Luke D. Lavis
    • , Pietro De Camilli
    • , James E. Rothman
    • , David Baddeley
    •  & Joerg Bewersdorf

News & Comment

  • Research Highlight |

    A protein co-regulation database facilitates proteome-wide functional annotations.

    • Philip Lössl
  • Comment |

    Advances in single-cell genomics technologies have enabled investigation of the gene regulation programs of multicellular organisms at unprecedented resolution and scale. Development of single-cell multimodal omics tools is another major step toward understanding the inner workings of biological systems.

    • Chenxu Zhu
    • , Sebastian Preissl
    •  & Bing Ren

Collection

Expanding the CRISPR Toolbox

The CRISPR-Cas9 system is best known for its ability to knock out or replace specific genes, via targeted cleavage of the genome. But scientists are developing many more applications, typically by using an inactive Cas9 to target other enzymes to specific genomic sites. From transcriptional regulation to base editing, these developments are extending the range of biological questions that can be probed with CRISPR/Cas9.

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