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Volume 10 Issue 4, April 2004

The protein Nogo is a well-known inhibitor of axonal outgrowth and repair in the nervous system. On page 382 of this issue, Acevedo et al. show that Nogo also acts in the vasculature, regulating remodeling in response to injury (see also the related News & Views on page 348). The cover image shows immunofluorescent staining of Nogo (red) in an uninjured femoral artery (phalloidin staining is in gree and DAPI staining in blue). Magnification, x63.

Volume 10 Issue 4

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Editorial

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News

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Correspondence

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Commentary

  • Human/nonhuman stem cell chimeras will be increasingly applied to study human cells in developing nonhuman animals. Such experiments raise a number of issues that may create further controversy in the stem cell field. Here we outline the scientific value and ethical ramifications of such studies, and suggest how such experiments may be conducted ethically.

    • Phillip Karpowicz
    • Cynthia B Cohen
    • Derek van der Kooy
    Commentary
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Book Review

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News & Views

  • Blocking activation of a death receptor enhances axonal regeneration and functional recovery in an animal model of spinal cord injury (pages 389–395).

    • Catherine Barthélémy
    • Christopher E Henderson
    News & Views

  • Locomotor activity in response to cocaine increases with repeated administration. A clever microarray approach now yields clues to the basis for this heightened sensitivity.

    • Pietro Paolo Sanna
    • George F Koob
    News & Views

  • The streptococcal toxic shock syndrome causes a massive leak of plasma from the circulation, leading to low blood pressure and respiratory failure. Now this leakage is traced to the effects of neutrophils activated by a bacterial surface protein.

    • Jonathan Cohen
    News & Views

  • Memory T cells in peripheral tissues such as the lung lie in wait, ready to attack pathogens that try to reinvade the body. Work on mice infected with the influenza virus now identifies a molecule that keeps these T cells in their positions, and prevents them from dying off.

    • Liisa K Selin
    • Markus Cornberg
    News & Views

  • An enhancer of the heat shock response alleviates symptoms of neurodegeneration and prolongs lifespan in a mouse model of amyotrophic lateral sclerosis—even when administered after onset (pages 402–405).

    • Susanna C Benn
    • Robert H Brown Jr
    News & Views

  • Migration and proliferation of smooth muscle cells after vascular injury can lead to dangerous vessel narrowing. A splice variant of Nogo, implicated in the inhibition of axonal regeneration, now appears to limit this smooth muscle accumulation (pages 382–388).

    • Elaine W Raines
    News & Views
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Historical News and Views

  • Well over ten years ago, hints begin to emerge that the melanocortin system, implicated in adrenal function and skin pigmentation, might also regulate energy balance. In the 1990s, speculation gave way to hard data: a melanocortin receptor highly expressed in the brain was firmly established as a central regulator of food intake and fat mass.

    • Stephen O'Rahilly
    • Giles S H Yeo
    • I Sadaf Farooqi
    Historical News and Views
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Historical Research Notes

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Historical Perspective

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Brief Communication

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Article

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Letter

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Technical Report

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Erratum

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Corrigendum

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On the Market

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