Reservoirs of virally infected cells that are resistant to standard antiretroviral therapy make HIV-1 infection an incurable disease. A new study shows that follicular T helper cells in lymph node germinal centers are prime niches for HIV-1 persistence during antiviral therapy.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Siliciano, J.D. et al. Nat. Med. 9, 727–728 (2003).
Whitney, J.B. et al. Nature 512, 74–77 (2014).
Allers, K. et al. Blood 117, 2791–2799 (2011).
Banga, R. et al. Nat. Med. 22, 754–761 (2016).
Locci, M. et al. Immunity 39, 758–769 (2013).
Kohler, S.L. et al. J. Immunol. 196, 2711–2722 (2016).
Heesters, B.A. et al. PLoS Pathog. 11, e1005285 (2015).
Fletcher, C.V. et al. Proc. Natl. Acad. Sci. USA 111, 2307–2312 (2014).
Fukazawa, Y. et al. Nat. Med. 21, 132–139 (2015).
Hale, J.S. & Ahmed, R. Front. Immunol. 6, 16 (2015).
Pallikkuth, S. et al. J. Virol. 90, 2718–2728 (2015).
Acknowledgements
M.P. is supported by NIH grants AI110334 and AI104278. M.L. is supported by NIH grants AI106468, AI114235, AI117841, AI120008 and AI098487.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Paiardini, M., Lichterfeld, M. Follicular T helper cells: hotspots for HIV-1 persistence. Nat Med 22, 711–712 (2016). https://doi.org/10.1038/nm.4138
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.4138