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| Editorials | Top |
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The world of biomedical research p607 doi:10.1038/nm0696-607a PDF
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More on death and dying p607 Barbara J. Culliton doi:10.1038/nm0696-607b PDF
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| Letters to the Editor | Top |
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Progress on polio in India p608 H.V. Wyatt doi:10.1038/nm0696-608a References | PDF
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Nonstop treatment of cystic fibrosis p608 Harry C. Dietz
& Ada Hamosh doi:10.1038/nm0696-608b References | PDF
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Reply to "Nonstop treatment of cystic fibrosis" pp608 - 609 David M. Bedwell, Marybeth Howard
& Raymond A. Frizzell doi:10.1038/nm0696-608c References | PDF
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A role for GAPDH in apoptosis and neurodegeneration pp609 - 610 De-Maw Chuang
& Ryoichi Ishitani doi:10.1038/nm0696-609 References | PDF
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Reply to "A role for GAPDH in apoptosis and neurodegeneration" p610 Allen D. Roses, James R. Burke, Jeffery M. Vance
& Warren J. Strittmatter doi:10.1038/nm0696-610a References | PDF
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Spectacles and young eyes pp610 - 611 Richard A. Stone, Alan M. Laties, Alcides Fernades
& Margarete Tigges doi:10.1038/nm0696-610b References | PDF
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Reply to "Spectacles and young eyes" pp611 - 612 Earl L. Smith III, Li-Fang Hung
& M.L.J. Crawford doi:10.1038/nm0696-611 References | PDF
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| News | Top |
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Genetic testing: Out of the bottle pp613 - 614 Orla Smith doi:10.1038/nm0696-613 PDF
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Making geneticists out of physicians p614 Adam Marcus doi:10.1038/nm0696-614 PDF
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Germany struggles with organ transplantation p615 Michael Simm doi:10.1038/nm0696-615 PDF
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Court approval of physician−assisted suicide p616 Adam Marcus doi:10.1038/nm0696-616 PDF
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Karen Ann Quinlan's legacy of controversy pp617 - 618 Vicki Brower doi:10.1038/nm0696-617 PDF
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France moves to right biotech wrongs p618 Catherine Tastemain doi:10.1038/nm0696-618 Abstract | PDF
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Complementing mainstream medicine pp619 - 620 Iris Kedar doi:10.1038/nm0696-619a PDF
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Washington State, Bastyr University lead natural medicine charge p619 Fintan R. Steele doi:10.1038/nm0696-619b PDF
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Online recruitment of clinical trial participants pays off p620 Fintan R. Steele doi:10.1038/nm0696-620 PDF
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Physicians seek business savvy p621 Sharon Kedar doi:10.1038/nm0696-621a PDF
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Japan's anti−AIDS drug arsenal slowly expands p621 Richard Nathan doi:10.1038/nm0696-621b PDF
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| Commentary & Review | Top |
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The advent of the 'unpatients' pp622 - 624 Albert R. Jonsen, Sharon J. Durfy, Wylie Burke
& Arno G. Motulsky doi:10.1038/nm0696-622 Abstract + references | PDF
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HIV viral load markers in clinical practice pp625 - 629 M.S. Saag, M. Holodniy, D.R. Kuritzkes, W.A. O'Brien, R. Coombs, M.E. Poscher, D.M. Jacobsen, G.M. Shaw, D.D. Richman
& P.A. Volberding doi:10.1038/nm0696-625 Abstract + references | PDF
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| News and Views | Top |
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Microsatellite instability: The mutator that mutates the other mutator pp630 - 631 Manuel Perucho doi:10.1038/nm0696-630 Abstract + references | PDF
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Serine protease inhibitors (SERPINS): Where mechanism meets medicine pp632 - 633 Harvey Rubin doi:10.1038/nm0696-632 Abstract + references | PDF
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Selective gene therapy for proliferative disorders: Sense and antisense pp634 - 635 Ciro Indolfi, Massimo Chiariello
& Enrico V. Avvedimento doi:10.1038/nm0696-634 Abstract + references | PDF
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Pyrazinamide on the antituberculosis drug frontline pp635 - 636 Denis A. Mitchison doi:10.1038/nm0696-635 Abstract + references | PDF
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Tissue sealants: Current status, future potential pp637 - 638 Mark R. Jackson doi:10.1038/nm0696-637 Abstract + references | PDF
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Banking on spermatogonial stem cells: Frozen assets and foreign investments pp638 - 639 Robin Lovell-Badge doi:10.1038/nm0696-638 Abstract + references | PDF
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Fusin − a place for HIV−1 and T4 cells to meet pp640 - 641 Dimiter S. Dimitrov doi:10.1038/nm0696-640 Abstract + references | PDF
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Ribozyme trans−splicing and RNA tagging: Following the messenger pp641 - 642 Nava Sarver
& Scott Cairns doi:10.1038/nm0696-641 Abstract + references | PDF
(280K)
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| Articles | Top |
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Tagging ribozyme reaction sites to follow trans−splicing in mammalian cells pp643 - 648 Joshua T. Jones, Seong-Wook Lee
& Bruce A. Sullenger doi:10.1038/nm0696-643 Abstract + references | PDF
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Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy pp649 - 654 Jean Bennett, Teruyo Tanabe, Dexue Sun, Yong Zeng, Hlld Kjeldbye, Peter Gouras
& Albert M. Maguire doi:10.1038/nm0696-649 Abstract + references | PDF
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Vacuolar myelopathy in transgenic mice expressing human immunodeficiency virus type 1 proteins under the regulation of the myelin basic protein gene promoter pp655 - 661 Guy Goudreau, Stirling Carpenter, Normand Beaulieu
& Paul Jolicoeur doi:10.1038/nm0696-655 Abstract + references | PDF
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Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus pp662 - 667 Angelo Scorpio
& Ying Zhang doi:10.1038/nm0696-662 Abstract + references | PDF
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Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase pp668 - 675 Brett P. Monia, Joseph F. Johnston, Thomas Geiger, Marcel Muller
& Doriano Fabbro doi:10.1038/nm0696-668 Abstract + references | PDF
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Somatic microsatellite mutations as molecular tumor clocks pp676 - 681 Darryl Shibata, William Navidi, Reijo Salovaara, Zhi-Hua Li
& Lauri A. Aaltonen doi:10.1038/nm0696-676 Abstract + references | PDF
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Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment pp682 - 685 Li Mao, Jin S. Lee, You H. Fan, Jae Y. Ro, John G. Batsakis, Scott Lippman, Walter Hittelman
& Waun K. Hong doi:10.1038/nm0696-682 Abstract + references | PDF
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Growth arrest of solid human neuroblastoma xenografts in nude rats by natural IgM from healthy humans pp686 - 689 Kerstin David, Markus W. Ollert, Hartmut Juhl, Caren Vollmert, Rudolf Erttmann, Carl-Wilhelm Vogel
& Reinhard Bredehorst doi:10.1038/nm0696-686 Abstract + references | PDF
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Angiostatin induces and sustains dormancy of human primary tumors in mice pp689 - 692 Michael S. O'Reilly, Lars Holmgren, Catherine Chen
& Judah Folkman doi:10.1038/nm0696-689 Abstract + references | PDF
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Reconstitution of spermatogenesis from frozen spermatogonial stem cells pp693 - 696 Mary R. Avarbock, Clayton. J. Brinster
& Ralph L. Brinster doi:10.1038/nm0696-693 Abstract + references | PDF
(657K)
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Intrathecal delivery of CNTF using encapsulated genetically modifiedxenogeneic cells in amyotrophic lateral sclerosis patients pp696 - 699 Patrick Aebischer, Myriam Schluep, Nicole Déglon, Jean-Marc Joseph, Lorenz Hirt, Bruno Heyd, Moses Goddard, Joseph P. Hammang, Anne D. Zurn, Ann C. Kato, Franco Regli
& E. Edward Baetge doi:10.1038/nm0696-696 Abstract + references | PDF
(496K)
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Striatal dopamine nerve terminal markers in human, chronic methamphetamine users pp699 - 703 Julie M. Wilson, Kathryn S. Kalasinsky, Allan I. Levey, Catherine Bergeron, Gregory Reiber, Robert M. Anthony, Gregory A. Schmunk, Kathleen Shannak, John W. Haycock
& Stephen J. Kish doi:10.1038/nm0696-699 Abstract + references | PDF
(547K)
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The role of endogenous nerve growth factor in human diabetic neuropathy pp703 - 707 P. Anand, G. Terenghi, G. Warner, P. Kopelman, R.E. Williams-Chestnut
& D.V. Sinicropi doi:10.1038/nm0696-703 Abstract + references | PDF
(641K)
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| Book Reviews | Top |
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Osier's Web p708 doi:10.1038/nm0696-708 PDF
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Genomic Imprinting pp709 - 710 doi:10.1038/nm0696-709 PDF
(276K)
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Genetics in Primary Care & Clinical Medicine pp710 - 711 doi:10.1038/nm0696-710 PDF
(314K)
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| New Technology | Top |
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Stereotactic radiosurgery pp712 - 713 Robert J. Maciunas doi:10.1038/nm0696-712 References | PDF
(279K)
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Second−generation adenovirus vectors pp714 - 716 Qing Wang
& Mitchell H. Finer doi:10.1038/nm0696-714 References | PDF
(850K)
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On the market pp717 - 719 doi:10.1038/nm0696-717 PDF
(426K)
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