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References
Yang, N-S. Gene transfer into mammalian somatic cells in vivo. Critical Rev. Biotech. 12, 335–356 (1992).
Kozarsdy, K.F., Wilson, J.M. Gene therapy: adenovirus vectors. Curr. Opin. Genet. Devel. 3, 499–503 (1993).
Jones, N., Shenk, T. Isolation of adenovirus type 5 host range deletion mutants defective for transformation in rat embryo cells. Cell 17, 683–689 (1979).
Reichel, R., Kovesdi, I., Nevins, M. Jr. Developmental control of a promoter-specific factor that is also regulated by the E1A gene product. Cell 48, 501–506 (1987).
Zhang, Y., Schneider, RJ. Adenovirus inhibition of cell translation facilitates release of virus particles and enhances degradation of the cy-tokeratin network. j. Viral. 68, 2544–2555 (1994).
Valentine, R.C., Pereira, H.G. Antigens and structure of the adenovirus. j. Mol. Biol. 13, 13–20 (1965).
Lochmuller, H.J. et al. Emergence of early region 1-containing replication-competent adenovirus in stocks of replication-defective adenovirus re-combinants (delta E1 + delta E3) during multiple passages in 293 cells. Hum. Gene Ther. 5, 1485–1491 (1994).
Yang, Y. et al. Cellular immunity to viral antigens limits El-deleted adenoviruses for gene therapy. Proc. Not. Acad. Sci. USA 91, 4407–4411 (1994).
Yang, Y., Ertl, H.C.J. & Wilson, J.M. MHC classl-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with El-deleted recombinant adenoviruses. Immunity 1, 433–442 (1994).
Flint, J. & Broker, T.R. Lytic infections by adenoviruses in Molecular Biology of Tumor Viruses: DNA Tumor Viruses 2nd edn. (ed. Tooze, J.) 443–454 (Cold Spring Harbor Laboratory, 1980).
Engelhardt, J.F., Ye, X., Doranz, B. & Wilson, J.M. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. USA 91, 6196–6200 (1994).
Golkman, M.J., Litzky, L.A., Engelhardt, J.F. & Wilson J.M. Transfer of the CFTR gene to the lung of nonhuman primates with El-deleted, E2a-defective recombinant adenoviruses: a pre-clinical toxicology study. Hum. Gene Ther. 6, 839–851 (1995).
Horwitz, M.S. Adenovirudae and their replication in Virology 2nd edn (ed. Fields, B.N. et al.) 1679 1721 (Raven Press, New York, 1994).
Fang, B. et al. Lack of persistence of El-recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in im-munocompetent mice and hemophilia B dogs. Gene Ther. 3, 217–222 (1996).
Hrisse, J. & Rigolet, M., Dupont de Dinechin, S. & Gaubert, F. Nucleotide sequence of adenovirus 2 DNA fragment encoding for the car-boxylic region of the fiber protein and the entire E4 region. Nucleic Acid Res. 9, 4022–4042 (1981).
Sandier, A.B. & ketner, G. Adenovirus early region 4 is essential for normal stability of late nuclear RNAs. J. Virol. 63, 624–630 (1989).
Halbert, D.N., Cutt, J.R. & Shenk, T. Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff. J. Virol. 56, 250–257 (1985).
Weinberg, D.H. & Ketner, G. Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression. J. Virol. 57, 833–838 (1986).
Ketner, G., Bridge, E., Virtanen, A., Hemstrom, C. & Pettersson, U. Complementation of adenovirus E4 mutants by transient expression of E4 cDNA and deletion plasmids. Nucleic Acids Res. 17, 3037–3048 (1989).
Babiss, L.E. & Ginsberg, H.S. Adenovirus type 5 early region Ib gene product is required for efficient shutoff of host protein synthesis. J. Virol. 50, 202–212 (1984).
Bridge, E., St Ketner, G. Interaction of adenoviral E4 and Elb products in late gene expression. Virology 174, 345–353 (1990).
Wang, Q. & Taylor, M.W. Correction of deletion mutant using adenovirus vector. Mol. Cell. Biol. 13, 918–927 (1993).
Ayumi, F., Keiko, S., Yumi, D., Izumu, S. & Ichizo, K. Gene targeting with a replication-defective adenovirus vector. J. Virol. 69, 6180–6190 (1995).
Klessig, K.F., Brough, K.E. & Cleghon, V. Introduction, stable integration, and controlled expression of a chimeric adenovirus gene whose product is toxic to the recipient human cell. Mol. Cell Biol. 4, 1354–1362 (1984).
Nevins, J.R. Regulation of early adenovirus gene expression. Microbiol Rev. 51, 419–430 (1987).
Su, J.J. & Hsueh, A.J.W. Characterization of mouse inhibin a gene and its promoter. Biochem. Biophys. Res, Commun. 186, 293–300 (1992).
Wang, Q., Jia, X.-C. & Finer, M.H. A packaging cell line for propagation of recombinant adenovirus vectors containing two lethal gene-region deletions. Gene Ther. 2, 775–783 (1995).
Kim, K.-S., Lee, M.K., Carroll, J. & Hob, T.H. Both the basal and inducible transcription of the tyrosine hydroxylase gene are dependent upon a cAMP response element. J. Biol. Chem. 268, 15689–15695 (1993).
Couture, L.A. et al. The use of alternative vectors for gene transfer to lung epithelia and tissue culture cells. Pedlatr. Pulm. Suppl. 8, 237 (1992).
Norrby, E. The relationship between soluble antigens and the virion of adenovirus type 3. 1. Morphological characteristics. Virology 28, 236–248 (1966).
Philipson, L., Pettersson, U. & Lindberg, U. Virus-receptor interaction in an adenovirus system. J. Virol. 2, 1064–1075 (1975).
Hierholzer, J.C. Further subgrouping of the human adenoviruses by differential hemaggluti-nation. J. Infect. Dis. 128, 541–550 (1973).
Dong, J.-Y., Wang, D., Van Ginkel, F.W., Pascual, D.W. & Frizzell, R.A. Systematic analysis of repeated gene delivery into animal lungs with a recombinant adenovirus vector. Hum. Gene Ther. 7, 319–331 (1996).
Van Ginkel, F.W. et al. Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and |3-galactosidase. Hum. Gene Ther. 6, 895–903 (1995).
Kass-Eisler, A., Leinwand, L., Gall, J., Bloom, B. & Falck-Pedersen, E. Circumventing the immune response to adenovirus-mediated gene therapy. Gene Ther. 3, 154–162 (1996).
Yang, Y., Trinchieri, G. & Wilson, J.M. Recombinant IL-2 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nature Med. 1, 890–893 (1995).
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Wang, Q., Finer, M. Second–generation adenovirus vectors. Nat Med 2, 714–716 (1996). https://doi.org/10.1038/nm0696-714
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DOI: https://doi.org/10.1038/nm0696-714
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