A new combinatorial approach harnesses the power of immuno- and virotherapy in a vesicular stomatitis virus (VSV) vector carrying a cDNA library that expresses normal human prostate antigens, thus providing proof of principle that this vaccine can induce prostate tumor rejection in mice (pages 854–859). This strategy might bypass many of the issues associated with conventional cancer immuno- or virotherapy.
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References
Chiocca, E.A. Curr. Opin. Mol. Ther. 10, 38–45 (2008).
Prestwich, R.J. et al. Hum. Gene Ther. 20, 1119–1132 (2009).
Koos, D. et al. Cell. Immunol. 263, 138–147 (2010).
Stratton, M.R., Campbell, P.J. & Futreal, P.A. Nature 458, 719–724 (2009).
Kottke, T. et al. Nat. Med. 17, 854–859 (2011).
Daniels, G.A. et al. Nat. Biotechnol. 22, 1125–1132 (2004).
Kottke, T. et al. Cancer Res. 69, 7767–7774 (2009).
Kalluri, R. & Weinberg, R.A. J. Clin. Invest. 119, 1420–1428 (2009).
Santisteban, M. et al. Cancer Res. 69, 2887–2895 (2009).
Phillips, H.S. et al. Cancer Cell 9, 157–173 (2006).
Qiao, J. et al. Nat. Med. 14, 37–44 (2008).
Seymour, L.W., Cawood, R. & Fisher, K.D. Curr. Opin. Mol. Ther. 10, 321–322 (2008).
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Alvarez-Breckenridge, C., Chiocca, E. A viral strategy to ambush tumors. Nat Med 17, 784–785 (2011). https://doi.org/10.1038/nm0711-784
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DOI: https://doi.org/10.1038/nm0711-784
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