Mammalian genomes harbor regulatory elements from ancient retroviral infections. These retroviral remnants are normally silenced by DNA methylation—but this can change. Reactivation of one such element triggers the expression of a nearby oncogene during the development of Hodgkin's lymphoma (571–579).
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Engel, M., Hiebert, S. The enemy within: dormant retroviruses awaken. Nat Med 16, 517–518 (2010). https://doi.org/10.1038/nm0510-517
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DOI: https://doi.org/10.1038/nm0510-517
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