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Letter
Nature Medicine 12, 824–828 (1 July 2006) | doi:10.1038/nm1418
Altered neuregulin 1|[ndash]|erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia
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Abstract
Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathophysiology of schizophrenia. Among NRG1 receptors, erbB4 is of particular interest because of its crucial roles in neurodevelopment and in the modulation of N-methyl-D-aspartate (NMDA) receptor signaling.
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