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Nature Medicine
ISSUE
November 2006, Volume 12 No 11
Editorial
News
Correspondence
Book Review
News and Views
Brief Communications
Articles
Technical Reports
Erratum
Corrigendum
About the cover
Editorial Top
In the eye of the beholder p1221
doi:10.1038/nm1106-1221
Abstract | Full text | PDF (63K)
News Top
Troubling reports tarnish credibility of US drug agency p1223
Meredith Wadman
Published online: 30 October 2006 | doi:10.1038/nm1106-1223
Full text | PDF (107K)
Younger scientists feel pinch of tightening research budgets p1224
Alisa Opar
Published online: 30 October 2006 | doi:10.1038/nm1106-1224a
Full text | PDF (101K)
New methods suggest AIDS toll lower than estimated p1224
Erika Check
Published online: 30 October 2006 | doi:10.1038/nm1106-1224b
Full text | PDF (101K)
Virtual models best live cells at predicting biology p1225
Alan Dove
Published online: 30 October 2006 | doi:10.1038/nm1106-1225a
Full text | PDF (95K)
India's polio exports undermine global eradication push p1225
T.V. Padma
Published online: 30 October 2006 | doi:10.1038/nm1106-1225b
Full text | PDF (95K)
News In brief pp1226 - 1227Published online: 30 October 2006 | 
doi:10.1038/nm1106-1226
Full text | PDF (274K)
News feature: A shot of fear pp1228 - 1229
Virginia Hughes
Published online: 30 October 2006 | doi:10.1038/nm1106-1228

Spooked by reports that vaccines might cause diseases such as autism, many parents choose not to vaccinate their kids. But when their decision endangers others, asks Virginia Hughes, should the government step in?

Abstract | Full text | PDF (134K)
Alice Dautry p1230
Declan Butler
Published online: 30 October 2006 | doi:10.1038/nm1106-1230

The first woman to head Paris's prestigious Institut Pasteur, Alice Dautry inherited an ugly mess. One year into the job, she has already succeeded in getting the center back on track.

Abstract | Full text | PDF (92K)
Correspondence Top
Melanoma pathogenesis and Nodal: a partial picture? p1231
David S Salomon
doi:10.1038/nm1106-1231a
Full text | PDF (78K)
Reply to Melanoma pathogenesis and Nodal: a partial picture? p1231
Jolanta M Topczewska, Lynne-Marie Postovit, Naira V Margaryan, Anthony Sam, Angela R Hess, William W Wheaton, Brian J Nickoloff, Jacek Topczewski & Mary J C Hendrix
doi:10.1038/nm1106-1231b
Full text | PDF (78K)
Challenges to the report of Nogo antibody effects in primates pp1231 - 1232
Mark Tuszynski
doi:10.1038/nm1106-1231c
Full text | PDF (95K)
Challenges to the report of Nogo antibody effects in primates p1232
Carole Ho & Marc Tessier-Lavigne
doi:10.1038/nm1106-1232a
Full text | PDF (81K)
Reply to Challenges to the report of Nogo antibody effects in primates pp1232 - 1233
Patrick Freund, Eric Schmidlin, Thierry Wannier, Jocelyne Bloch, Anis Mir, Martin E Schwab & Eric M Rouiller
doi:10.1038/nm1106-1232b
Full text | PDF (93K)
Book Review Top
Getting away with it p1235
Clare Thomas reviews Intuition by Allegra Goodman
doi:10.1038/nm1106-1235
Full text | PDF (77K)
News and Views Top
Stem cells: the good, bad and barely in control pp1237 - 1238
Christian T Carson, Stefan Aigner & Fred H Gage
doi:10.1038/nm1106-1237

The goal of replacing dying cells in Parkinson disease with stem cells is now brought a step closer to the clinic. A new protocol eases symptoms in a rat model of the disease, but also raises the concern that poorly differentiated cells have the potential to become tumorigenic (pages 1259–1268).

Abstract | Full text | PDF (215K)
See also: Article by Roy et al.
Transcription meets metabolism in neurodegeneration pp1239 - 1241
Christopher A Ross & Leslie Michels Thompson
doi:10.1038/nm1106-1239

A molecular basis for the metabolic abnormalities observed in Huntington disease is emerging. Transcription of a key mitochondrial regulator, PGC-1alpha, is dysregulated by mutant huntingtin, leading to oxidative stress and excitotoxicity. The findings dovetail with previous work implicating aberrant transcription in Huntington disease, and have implications for related conditions such as Parkinson disease.

Abstract | Full text | PDF (346K)
Alzheimer's APP mangles mitochondria pp1241 - 1243
Michael T Lin & M Flint Beal
doi:10.1038/nm1106-1241

New findings in humans examine how mitochondrial function declines during Alzheimer disease.

Abstract | Full text | PDF (208K)
Feeling pain? Who's your daddy... pp1243 - 1244
Gavril W Pasternak & Charles E Inturrisi
doi:10.1038/nm1106-1243

A new modulator of pain comes to light in studies of rats and people (pages 1269–1277).

Abstract | Full text | PDF (108K)
See also: Article by Tegeder et al.
Feeding signals and drugs meet in the midbrain pp1244 - 1246
Richard Simerly
doi:10.1038/nm1106-1244

Three studies show that overeating may share neurobiological mechanisms with the addictive properties of drugs of abuse.

Abstract | Full text | PDF (155K)
Virus scores a perfect 10 pp1246 - 1248
Paul Klenerman & Burkhard Ludewig
doi:10.1038/nm1106-1246

Blockade of a single cytokine—interleukin-10—can re-energize T cells 'exhausted' by persistent virus infection. The findings have implications for controlling HIV and other persistent viruses (pages 1301–1309).

Abstract | Full text | PDF (204K)
See also: Article by Brooks et al.
Keeping the fat off with nesfatin pp1248 - 1249
Martin G Myers Jr
doi:10.1038/nm1106-1248

A newly described neuropeptide, nesfatin-1, acts in the brain to suppress appetite.

Abstract | Full text | PDF (166K)
Research Highlights pp1250 - 1251
doi:10.1038/nm1106-1250
Full text | PDF (161K)
Brief Communications Top
Identification of a hormonal basis for gallbladder filling pp1253 - 1255
Mihwa Choi, Antonio Moschetta, Angie L Bookout, Li Peng, Michihisa Umetani, Sam R Holmstrom, Kelly Suino-Powell, H Eric Xu, James A Richardson, Robert D Gerard, David J Mangelsdorf & Steven A Kliewer
Published online: 29 October 2006 | doi:10.1038/nm1501
Abstract | Full text | PDF (160K)  | Supplementary Information
Molecular ablation of ventricular tachycardia after myocardial infarction pp1256 - 1258
Tetsuo Sasano, Amy D McDonald, Kan Kikuchi & J Kevin Donahue
Published online: 29 October 2006 | doi:10.1038/nm1503
Abstract | Full text | PDF (237K)  | Supplementary Information
Articles Top
Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes pp1259 - 1268
Neeta S Roy, Carine Cleren, Shashi K Singh, Lichuan Yang, M Flint Beal & Steven A Goldman
Published online: 22 October 2006 | doi:10.1038/nm1495
Abstract | Full text | PDF (857K)  | Supplementary Information
See also: News and Views by Carson et al.
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence pp1269 - 1277
Irmgard Tegeder, Michael Costigan, Robert S Griffin, Andrea Abele, Inna Belfer, Helmut Schmidt, Corina Ehnert, Jemiel Nejim, Claudiu Marian, Joachim Scholz, Tianxia Wu, Andrew Allchorne, Luda Diatchenko, Alexander M Binshtok, David Goldman, Jan Adolph, Swetha Sama, Steven J Atlas, William A Carlezon, Aram Parsegian, Jörn Lötsch, Roger B Fillingim, William Maixner, Gerd Geisslinger, Mitchell B Max & Clifford J Woolf
Published online: 22 October 2006 | doi:10.1038/nm1490
Abstract | Full text | PDF (510K)  | Supplementary Information
See also: News and Views by Pasternak & Inturrisi
Activated protein C inhibits tissue plasminogen activator–induced brain hemorrhage pp1278 - 1285
Tong Cheng, Anthony L Petraglia, Zhang Li, Meenakshisundaram Thiyagarajan, Zhihui Zhong, Zhenhua Wu, Dong Liu, Sanjay B Maggirwar, Rashid Deane, José A Fernández, Barbra LaRue, John H Griffin, Michael Chopp & Berislav V Zlokovic
Published online: 29 October 2006 | doi:10.1038/nm1498
Abstract | Full text | PDF (362K)  | Supplementary Information
Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death pp1286 - 1293
Vineet Bhandari, Rayman Choo-Wing, Chun G Lee, Zhou Zhu, Jonathan H Nedrelow, Geoffrey L Chupp, Xucher Zhang, Michael A Matthay, Lorraine B Ware, Robert J Homer, Patty J Lee, Anke Geick, Antonin R de Fougerolles & Jack A Elias
Published online: 05 November 2006 | doi:10.1038/nm1494
Abstract | Full text | PDF (464K)  | Supplementary Information
Genomic signatures to guide the use of chemotherapeutics pp1294 - 1300
Anil Potti, Holly K Dressman, Andrea Bild, Richard F Riedel, Gina Chan, Robyn Sayer, Janiel Cragun, Hope Cottrill, Michael J Kelley, Rebecca Petersen, David Harpole, Jeffrey Marks, Andrew Berchuck, Geoffrey S Ginsburg, Phillip Febbo, Johnathan Lancaster & Joseph R Nevins
Published online: 22 October 2006 | doi:10.1038/nm1491
Abstract | Full text | PDF (563K)  | Supplementary Information
Interleukin-10 determines viral clearance or persistence in vivo pp1301 - 1309
David G Brooks, Matthew J Trifilo, Kurt H Edelmann, Luc Teyton, Dorian B McGavern & Michael B A Oldstone
Published online: 15 October 2006 | doi:10.1038/nm1492
Abstract | Full text | PDF (483K)  | Supplementary Information
See also: News and Views by Klenerman & Ludewig
Technical Reports Top
Quantification of antibody responses against multiple antigens of the two infectious forms of Vaccinia virus provides a benchmark for smallpox vaccination pp1310 - 1315
Mike M Pütz, Claire M Midgley, Mansun Law & Geoffrey L Smith
Published online: 05 November 2006 | doi:10.1038/nm1457
Abstract | Full text | PDF (387K)  | Supplementary Information
Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1 pp1316 - 1322
Michael W Melkus, Jacob D Estes, Angela Padgett-Thomas, Joel Gatlin, Paul W Denton, Florence A Othieno, Anja K Wege, Ashley T Haase & J Victor Garcia
Published online: 22 October 2006 | doi:10.1038/nm1431
Abstract | Full text | PDF (720K)  | Supplementary Information
A male contraceptive targeting germ cell adhesion pp1323 - 1328
Dolores D Mruk, Ching-Hang Wong, Bruno Silvestrini & C Yan Cheng
Published online: 29 October 2006 | doi:10.1038/nm1420
Abstract | Full text | PDF (511K)  | Supplementary Information
Erratum Top
Erratum: LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia p1329
Julia Skokowa, Gunnar Cario, Murat Uenalan, Axel Schambach, Manuela Germeshausen, Karin Battmer, Cornelia Zeidler, Ulrich Lehmann, Matthias Eder, Christopher Baum, Rudolf Grosschedl, Martin Stanulla, Michaela Scherr & Karl Welte
doi:10.1038/nm1106-1329a
Full text | PDF (49K)
Corrigendum Top
Corrigendum: Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction p1329
L Trautmann, L Janbazian, N Chomont, E A Said, S Gimmig, B Bessette, M-R Boulassel, E Delwart, H Sepulveda, R S Balderas, J-P Routy, E K Haddad & R-P Sekaly
doi:10.1038/nm1106-1329b
Full text | PDF (49K)
  Top
 
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ISSN: 1078-8956
EISSN: 1546-170X
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