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Volume 12 Issue 10, October 2006

The cover shows a transmission electron micrograph of H5N1 human influenza virus particles isolated from an infected human in Vietnam. On page 1203, de Jong and colleagues report findings from immunological and virological studies of 18 people infected with H5N1 in Vietnam. Their analysis provides clues about why H5N1 is so lethal to humans. Image courtesy of ©, NIBSC/PHOTO RESEARCHERS,INC.

Volume 12 Issue 10

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  • Thickening of the cardiac valves leads to congestive heart failure, chest pain, sudden loss of consciousness and often death. Experiments in mice now link this condition to dysregulation of an endogenous inhibitor of angiogenesis (1151–1159).

    • Raghu Kalluri
    • Elisabeth Zeisberg
    News & Views

  • A variant gene for antigen presentation is associated with tissue damage in multiple sclerosis. The damaging effects are now shown to be dampened by an allele of a second, neighboring gene.

    • John Trowsdale
    News & Views

  • Presenilins are thought to contribute to Alzheimer disease through a protein cleavage reaction that produces neurotoxic amyloid-β peptides. A new function for presenilins now comes to light—controlling the leakage of calcium out of the endoplasmic reticulum. Is this a serious challenge to the 'amyloid hypothesis' of Alzheimer disease?

    • Sam Gandy
    • Mark K Doeven
    • Bert Poolman
    News & Views

  • HIV causes a chronic infection that overwhelms the immune system and leads to T-cell exhaustion. Three groups now report that a signaling molecule that dampens immune responses may tucker out the T cells (1198–1202).

    • Alison Farrell
    News & Views

  • Many individuals with chronic myeloid leukemia have benefited from the drug imatinib (Gleevec)—but if they are taken off the drug, relapse occurs. Two mathematical models to explain this phenomenon, one described in this issue, have come to different conclusions (1181–1184).

    • Dominik Wodarz
    News & Views
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