Volume 11 Issue 12, December 2005

Abdominal aortic aneurysms can lead to aortic rupture and death. As shown by Aoki and colleagues on page 1330 of this issue, inhibition of Jnk kinase can cause regression of aortic aneurysms in mouse models. The cover image shows decreased dilation and more normal morphology of an aorta after treatment with a Jnk inhibitor.

Editorial

May you not live in interesting times

Editorial 01 Dec 2005

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News

Spirituality's rising role in medicine stirs debate

Critics say religion has no place in science.

Paroma Basu
News 30 Nov 2005
Global polio campaign doomed to fail, experts warn

Virus shed by vaccinated individuals could keep the virus in circulation for decades

Bruce Diamond
News 30 Nov 2005
Europe's restrictive rules strangling clinical research

The number of new trials is down by nearly half since the launch of new rules.

Xavier Bosch
News 29 Nov 2005
Caution on circumcision cuts South Africa's AIDS researchers

Is there is enough evidence to adopt circumcision as policy?

Lauren Beukes
News 30 Nov 2005
Price of mice to plummet under NIH's new scheme

The agency is set to provide knockout mice for just $115 each.

Emily Waltz
News 30 Nov 2005
Changing ethics rules land Spanish stem cell scientist in hot water

Researcher faces legal action because of new informed consent rules.

Xavier Bosch
News 30 Nov 2005
Blood pressure vaccine shot down by safety concerns

The vaccines may inevitably trigger an autoimmune response.

Tinker Ready
News 30 Nov 2005
News In Brief

News 01 Dec 2005
2005 In Review

News 01 Dec 2005

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Correspondence

A knock-out punch?

David H Sachs
Correspondence 01 Dec 2005

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Book Review

Raising voices, changing lives

Carolyn Kaelin
Book Review 01 Dec 2005

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News & Views

A radically twisted lipid regulates vascular death

Maintenance of the retinal vasculature protects against proliferative retinopathy and blindness. Lipids and free radicals together modulate vascular stability through regulation of antiangiogenic proteins (pages 1339–1345).

Lois E H Smith
Kip M Connor
News & Views 01 Dec 2005
More neurons, less weight

Treatment with a neuronal growth factor stimulates weight loss—and spurs the development of new neurons that help maintain reduced weight.

Randy J Seeley
News & Views 01 Dec 2005
Savior and slayer: the two faces of p53

Low levels of DNA damage caused by oxidative stress can be repaired, whereas extensive damage usually results in cell death. p53 contributes to both outcomes by stimulating expression of either pro- or antioxidant genes (pages 1306–1313).

Karim Bensaad
Karen H Vousden
News & Views 01 Dec 2005
Aneurysm treatments expand

Abdominal aortic aneurysms arise from chronic, irreversible destruction of connective tissue. A promising pharmacologic approach not only suppresses development of aneurysms, but also induces regression (pages 1330–1338).

Robert W Thompson
News & Views 01 Dec 2005
Oxidative stress is the new stress

Emotional stress may increase anxiety, but in mice, a different kind of stress—oxidative stress—may also contribute to anxious behavior.

Jay A Gingrich
News & Views 01 Dec 2005
Memory stem cells sustain disease

A rare memory stem cell has been discovered that sustains graft-versus-host disease in animal models (pages 1299–1305)

Xue-Zhong Yu
Claudio Anasetti
News & Views 01 Dec 2005
Locating heart failure

Local levels of cAMP regulate the precise opening of the ryanodine receptor complex—which releases calcium at the start of a heartbeat. Loss or inhibition of phosphodiesterase 4D enzymatic activity leads to calcium leak, heart failure and arrhythmia.

Jeffery D Molkentin
News & Views 01 Dec 2005
Wasting away

Alison Farrell
News & Views 01 Dec 2005
Research Highlights

News & Views 01 Dec 2005