An epitranscriptomic vulnerability in myeloid malignancies

Latest Research

  • Article |

    Fry et al. report the first results from a human trial of a CD22-directed chimeric antigen receptor (CAR) T cell therapy providing evidence of efficacy in the treatment of pre–B cell acute lymphoblastic leukemia that is immunotherapy-naive or resistant to CD19-directed CAR T cells.

    • Terry J Fry
    • , Nirali N Shah
    • , Rimas J Orentas
    • , Maryalice Stetler-Stevenson
    • , Constance M Yuan
    • , Sneha Ramakrishna
    • , Pamela Wolters
    • , Staci Martin
    • , Cindy Delbrook
    • , Bonnie Yates
    • , Haneen Shalabi
    • , Thomas J Fountaine
    • , Jack F Shern
    • , Robbie G Majzner
    • , David F Stroncek
    • , Marianna Sabatino
    • , Yang Feng
    • , Dimiter S Dimitrov
    • , Ling Zhang
    • , Sang Nguyen
    • , Haiying Qin
    • , Boro Dropulic
    • , Daniel W Lee
    •  & Crystal L Mackall
  • Article |

    Tumor organoids derived from the most common subtypes of primary liver cancer recapitulate the histologic and molecular features of the tissues of origin, even after long-term culture. These in vitro models, as well as those for colorectal cancer reported in Crespo et al. in a previous issue, are amenable for drug screening and allow the identification of therapeutic approaches with potential for cancer treatment.

    • Laura Broutier
    • , Gianmarco Mastrogiovanni
    • , Monique MA Verstegen
    • , Hayley E Francies
    • , Lena Morrill Gavarró
    • , Charles R Bradshaw
    • , George E Allen
    • , Robert Arnes-Benito
    • , Olga Sidorova
    • , Marcia P Gaspersz
    • , Nikitas Georgakopoulos
    • , Bon-Kyoung Koo
    • , Sabine Dietmann
    • , Susan E Davies
    • , Raaj K Praseedom
    • , Ruby Lieshout
    • , Jan N M IJzermans
    • , Stephen J Wigmore
    • , Kourosh Saeb-Parsy
    • , Mathew J Garnett
    • , Luc JW van der Laan
    •  & Meritxell Huch
  • Article |

    Pule and colleagues identify the TCR β-chain constant region as a new target for chimeric antigen receptor (CAR) T cells in treatment of T cell cancers while potentially preserving a healthy T cell repertoire. They demonstrate that anti-TCRB1 CAR T cells eliminate cancerous TCRB1+ T cells while sparing nearly one-third of normal TCRB2+ T cells.

    • Paul M Maciocia
    • , Patrycja A Wawrzyniecka
    • , Brian Philip
    • , Ida Ricciardelli
    • , Ayse U Akarca
    • , Shimobi C Onuoha
    • , Mateusz Legut
    • , David K Cole
    • , Andrew K Sewell
    • , Giuseppe Gritti
    • , Joan Somja
    • , Miguel A Piris
    • , Karl S Peggs
    • , David C Linch
    • , Teresa Marafioti
    •  & Martin A Pule
  • Article |

    Calcium cycling induced by the SERCA2b–RyR2 pathway in beige fat cells allows for thermogenic activity independent of UCP1.

    • Kenji Ikeda
    • , Qianqian Kang
    • , Takeshi Yoneshiro
    • , Joao Paulo Camporez
    • , Hiroko Maki
    • , Mayu Homma
    • , Kosaku Shinoda
    • , Yong Chen
    • , Xiaodan Lu
    • , Pema Maretich
    • , Kazuki Tajima
    • , Kolapo M Ajuwon
    • , Tomoyoshi Soga
    •  & Shingo Kajimura
  • Technical Report |

    Genetic cell-lineage tracing studies in mice are crucial for delineating the contribution of stem and progenitor cells to different cell types, both in disease states and after regenerative therapy. He et al. have developed new genetic lineage-tracing systems that provide more definitive results than the commonly used Cre-based system and show that this new technology can resolve current controversies in the field, as demonstrated by lineage-tracing studies in the heart and liver.

    • Lingjuan He
    • , Yan Li
    • , Yi Li
    • , Wenjuan Pu
    • , Xiuzhen Huang
    • , Xueying Tian
    • , Yue Wang
    • , Hui Zhang
    • , Qiaozhen Liu
    • , Libo Zhang
    • , Huan Zhao
    • , Juan Tang
    • , Hongbin Ji
    • , Dongqing Cai
    • , Zhibo Han
    • , Zhongchao Han
    • , Yu Nie
    • , Shengshou Hu
    • , Qing-Dong Wang
    • , Ruilin Sun
    • , Jian Fei
    • , Fengchao Wang
    • , Ting Chen
    • , Yan Yan
    • , Hefeng Huang
    • , William T Pu
    •  & Bin Zhou

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