Neutrophils can respond to many chemotactic signals, but how these cells 'prioritize' such signals to react to invading pathogens has remained unclear. The phosphatase PTEN seems to be critical in directing the migration of neutrophils toward their end target in a complex milieu of competing signals.
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Change history
21 July 2008
In the version of this article initially published, phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) is incorrectly identified as phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2). The error has been corrected in the HTML and PDF versions of the article.
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Billadeau, D. PTEN gives neutrophils direction. Nat Immunol 9, 716–718 (2008). https://doi.org/10.1038/ni0708-716
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DOI: https://doi.org/10.1038/ni0708-716
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