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Volume 8 Issue 6, June 2007

Reis e Sousa and colleagues report that stimulation of dectin-1 on dendritic cells by candida elicits CARD9-dependent signaling that leads to the development of TH-17 cells (p 630; see also News and Views by Palm and Medzhitov, p 549). The original image (bottom; by Alexander D. Edwards and Caetano Reis e Sousa) shows bone marrow-derived dendritic cells stained with phalloidin to demonstrate polymerized actin filaments. Artwork by Lewis Long.

Volume 8 Issue 6

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Editorial

  • Constructive dialog on manuscripts and publishing decisions ultimately improves manuscript quality.

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Essay

  • Innate immunity has come to the forefront in immunology, aided by the discovery of antifungal defense in drosophila. Here Jules Hoffmann recounts his team's pioneering work on insect immunity.

    • Jules Hoffmann
    Essay
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Commentary

  • Investigations of immune recognition in nonmammalian species provide new insights into the evolution of immunity and the inner workings of the mammalian immune system. Very diverse mechanisms are used by different multicellular organisms to recognize and cope with the rapidly evolving microbial world.

    • Gary W Litman
    • Max D Cooper
    Commentary
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News & Views

  • Fungal recognition occurs partially through the C-type lectin dectin-1. New studies show that dectin-mediated immune recognition of Candida albicans induces the differentiation of interleukin 17–producing T helper cells that express chemokine receptors characteristic of mucosal homing.

    • Noah W Palm
    • Ruslan Medzhitov
    News & Views

  • AID acts to further refine the immunoglobulin response in fish, birds and mammals. Now, evidence is uncovered to suggest AID actually arose early in evolution and can diversify antigen receptors in lampreys.

    • David G Schatz
    News & Views

  • Multiple receptors alert cells to microbial invasion by initiating intracellular signals that modify gene expression. New work provides a more complex view of microbe-induced signaling through the adaptor CARD9.

    • Marco Colonna
    News & Views

  • Human immunodeficiency virus uses many signaling pathways and cell surface receptors to infect cells. New work emphasizes the many functions of the lectin DC-SIGN expressed in dendritic cells.

    • Anthony L Cunningham
    • Andrew N Harman
    • Heather Donaghy
    News & Views

  • Dendritic cells are specialized in antigen presentation to lymphocytes. New research clarifies the origin and kinetics of differentiation of a subset of dendritic cells in the spleen and lymph nodes.

    • Frederic Geissmann
    News & Views
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Perspective

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Article

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