Review abstract
Nature Immunology 8, 1179 - 1187 (2007)
Published online: 19 October 2007 | Corrected online: 17 December 2007 | doi:10.1038/ni1528
There is an Erratum (January 2008) associated with this Review.
Pathogen subversion of cell-intrinsic innate immunity
Craig R Roy1 & Edward S Mocarski2
Abstract
The mammalian immune system has evolved under continuous selective pressure from a wide range of microorganisms that colonize and replicate in animal hosts. A complex set of signaling networks initiate both innate and adaptive immunity in response to the diverse pathogens that mammalian hosts encounter. In response, viral and microbial pathogens have developed or acquired sophisticated mechanisms to avoid, counteract and subvert sensors, signaling networks and a range of effector functions that constitute the host immune response. This balance of host response and pathogen countermeasures contributes to chronic infection in highly adapted pathogens that have coevolved with their host. In this review we outline some of the themes that are beginning to emerge in the mechanisms by which pathogens subvert the early innate immune response.
- Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut 06535, USA.
- Department of Microbiology & Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Correspondence to: Craig R Roy1 e-mail: craig.roy@yale.edu
Correspondence to: Edward S Mocarski2 e-mail: mocarski@emory.edu
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