Nature Immunology 7, 123 - 124 (2006)
doi:10.1038/ni0206-123
Mal-function of TLRs by SOCSTakashi Kobayashi, Giichi Takaesu
& Akihiko Yoshimura
Takashi Kobayashi, Giichi Takaesu and Akihiko Yoshimura are with the Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan. yakihiko@bioreg.kyushu-u.ac.jp
Suppressor of cytokine signaling 1 has been linked to the negative regulation of Toll-like receptor signaling. The mechanism for this seems to be suppressor of cytokine signaling 1–mediated degradation of the adaptor Mal, which is required for Toll-like receptor signaling.
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